Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India. Issue 5 (25th April 2013)

• Record Type: Journal Article
• Authors: Sodhi, Jaswinder Singh; Javid, Gul; Zargar, Showkat Ali; Tufail, Syed; Shah, Altaf; Khan, Bashir Ahmad; Yattoo, Ghulam Nabi; Gulzar, Ghulam Mohamad; Khan, Mushtaq Ahmad; Lone, Mohd Iqbal; Saif, Riyaz u; Parveen, Shaheena; Shoukat, Abid
• Is Part Of: Journal of gastroenterology and hepatology. Volume 28:Issue 5(2013:May)
• Page Start: 808
• Page End: 813
• Publication Date: 2013-04-25
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12178
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12178-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>Epidemiology of <italic>Helicobacter pylori</italic> infection has regional variation. Effect of eradication of <italic>H. pylori</italic> on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see <italic>H. pylori</italic> positivity rate in patients of functional dyspepsia and the effect of its eradication on symptoms.</p> </sec> <sec id="jgh12178-sec-0002" sec-type="section"> <title>Methods</title> <p>Randomized, double‐blind, placebo‐controlled study was the study design used. Patients of functional dyspepsia defined as per Rome 2 criteria were tested for <italic>H. pylori</italic> infection by rapid urease test and gastric biopsy. <italic>H. pylori</italic>‐positive patients were randomly allocated to triple therapy (20 mg of omeprazole, 500 mg of clarithromycin, and 1000 mg of amoxicillin orally two times daily) and omeperazole plus identical placebo for 2 weeks. Symptoms were assessed with the weekly Likert scale.</p> </sec> <sec id="jgh12178-sec-0003" sec-type="section"> <title>Results</title> <p> <italic>H. pylori</italic> positivity rate in functional dyspepsia was 1160/2000 (58%). At 6 weeks, the eradication rate for <italic>H. pylori</italic> in triple therapy and placebo group was (181/259 [69.8%] and 13/260 [5.0%], <italic>P</italic> = 0.001), respectively. On intention‐to‐treat analysis, the symptom resolution at 1 month was (157/259 [60.7%] and 136/260 [52.3%], <italic>P</italic> = 0.38), respectively. At 12 months, <italic>H. pylori</italic> eradication and healing of gastritis in triple therapy and placebo group were (116/174 [66.7%] and 12/180 [6.7%], <italic>P</italic> = 0.001) and (132/174 [75.9%] and 11/180 [6.1%], <italic>P</italic> = 0.001), respectively. On intension to treat, the resolution of symptoms in triple therapy and placebo group was (95/217 [43.7%] and 72/195 [36.9%], <italic>P</italic> = 0.13).</p> </sec> <sec id="jgh12178-sec-0004" sec-type="section"> <title>Conclusion</title> <p>There is high <italic>H. pylori</italic> positivity rate in patients of functional dyspepsia. The eradication of <italic>H. pylori</italic> does not resolve the symptoms despite healing of gastritis.</p> </sec> </abstract>