Depression and cardiovascular risk factors: evidence from a large postmortem sample1. (29th June 2012)

• Record Type: Journal Article
• Authors: Suemoto, Claudia K.; Damico, Marcio V.; Ferretti, Renata E. L.; Grinberg, Lea T.; Farfel, José Marcelo; Leite, Renata E. P.; Nitrini, Ricardo; Lafer, Beny; Jacob‐Filho, Wilson; Pasqualucci, Carlos A.; Group, Brazilian Aging Brain Study
• Is Part Of: International journal of geriatric psychiatry. Volume 28:Number 5(2013:May)
• Page Start: 487
• Page End: 493
• Publication Date: 2012-06-29
• Subjects: Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.3850
• Languages: English
• ISSNs: 0885-6230

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="gps3850-sec-0001" sec-type="section"> <title>Objectives</title> <p>We aimed to investigate the association of depression with cardiovascular risk factors and diseases (CVRFD) in a large population‐based sample.</p> </sec> <sec id="gps3850-sec-0002" sec-type="section"> <title>Methods</title> <p>This cross‐sectional study included 1012 deceased individuals greater than 50 years of age from a general autopsy service located in São Paulo, Brazil. Demographics, socioeconomic profile, and CVRFD information were collected by caregivers from the deceased individuals from the Brain Bank of the Brazilian Aging Brain Study Group. Depression diagnosed using the Structured Clinical Interview for Diagnostic and Statistical Mental Disorders was the main outcome.</p> </sec> <sec id="gps3850-sec-0003" sec-type="section"> <title>Results</title> <p>Depression was associated with female gender (odds ratio (OR) = 1.86; 95% confidence interval (CI) = 1.28–2.71, <italic>p</italic> = 0.001), widowhood (OR = 1.54; 95% CI = 1.03–2.32, <italic>p</italic> = 0.04), physical inactivity (OR = 1.61; 95% CI = 1.15–2.26, <italic>p</italic> = 0.006), and smoking (OR = 2.03; 95% CI = 1.40–2.95, <italic>p</italic> < 0.001) after multivariate logistic regression analysis. Other CVRFD were not associated with the presence of depression.</p> </sec> <sec id="gps3850-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In our cross‐sectional study, sedentary individuals and smokers showed a higher chance of depression during lifetime. Measures to control these common risk factors could decrease the incidence of depression. Copyright © 2012 John Wiley & Sons, Ltd.</p> </sec> </abstract>