Paediatric normative data for urine NGAL/creatinine ratio. (20th March 2013)

• Record Type: Journal Article
• Authors: Rybi–Szumińska, Agnieszka; Wasilewska, Anna; Litwin, Miecyslaw; Kułaga, Zbigniew; Szumiński, Michal
• Is Part Of: Acta pædiatrica. Volume 102:Number 6(2013:Jun.)
• Page Start: e269
• Page End: e272
• Publication Date: 2013-03-20
• Subjects: Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.12200
• Languages: English
• ISSNs: 0803-5253

Abstract

<abstract abstract-type="main" xml:lang="en" id="apa12200-abs-0001"> <title>Abstract</title> <sec id="apa12200-sec-0001" sec-type="section"> <title>Aim</title> <p>The objective of this study was to establish age‐dependent urine NGAL (neutrophil gelatinase‐associated lipocalin)/creatinine ratio values in healthy children and adolescents.</p> </sec> <sec id="apa12200-sec-0002" sec-type="section"> <title>Methods</title> <p>The study was performed using a random sample of 172 healthy children and adolescents (M–88, F–84), aged median 9.75 (0.2–17.9) years. Urine NGAL concentration was measured using a commercially available ELISA kit (R&D Systems, USA).</p> </sec> <sec id="apa12200-sec-0003" sec-type="section"> <title>Results</title> <p>Median concentrations of urine NGAL/creatinine in particular age groups were analysed using <sc>anova</sc>. The differences between the youngest group of children under the age of 6 years and the rest of examined population were statistically significant. There were no differences in urine NGAL/creatinine between other age groups. Statistically significant negative correlation between urine NGAL/creatinine and age of subjects was found (r = −0.29, p < 0.05).</p> </sec> <sec id="apa12200-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In the study, normative values of urine NGAL/creatinine for subjects aged 0.2–17.9 years have been established. These data may help clinicians and researchers to improve the interpretation of urine NGAL/creatinine ratio in children and adolescents. However, further studies using numerous data should be conducted to add reference values for urine NGAL partitioned by age and gender.</p> </sec> </abstract>