Vkorc1 variation in house mice during warfarin and difenacoum field trials. Issue 3 (23rd April 2012)

• Record Type: Journal Article
• Authors: Endepols, Stefan; Klemann, Nicole; Song, Ying; Kohn, Michael H
• Is Part Of: Pest management science. Volume 69:Issue 3(2013:Mar.)
• Page Start: 409
• Page End: 413
• Publication Date: 2012-04-23
• Subjects: Pests -- Control -- Periodicals; Pesticides -- Periodicals; 632.9
• DOI: 10.1002/ps.3306
• Languages: English
• ISSNs: 1526-498X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p> <bold>BACKGROUND: Field studies guided by genetic monitoring of <italic>Vkorc1</italic> need to be done to implicate mutations conclusively with rodent control problems due to the presence of animals resistant to anticoagulant rodenticides. Rodent control success in relation to <italic>Vkorc1</italic> genotypes in house mice (<italic>Mus musculus domesticus</italic>) was studied on two farms (I and II) in Germany. Tests were carried out to determine whether certain resistance profiles and <italic>Vkorc1</italic> genotypes displayed dynamics over the course of sequential treatments with warfarin and difenacoum that were consistent with single nucleotide polymorphisms (SNPs) in <italic>Vkorc1</italic> as indicators of resistance.</bold> </p> <p> <bold>RESULTS: On farms I and II, respectively, three (A to C) and two (A and B) types of control problem with anticoagulants (i.e. proxies for resistance) were encountered in spatially segregated subunits: A = none; B = control problems with warfarin but not with difenacoum; C = control problems with both anticoagulants. Unexpectedly, resistance was encountered in a population where only <italic>Vkorc1</italic> wild‐type mice were detected. In addition, the Arg58Gly <italic>Vkorc1</italic> variant was found not to correlate with observed control failures.</bold> </p> <p> <bold>CONCLUSION: Control problems were encountered that cannot be explained by <italic>Vkorc1</italic> coding or intronic SNPs, and therefore are likely due to non‐coding <italic>Vkorc1</italic> SNPs or due to other genetic or non‐genetic factors. © 2012 Society of Chemical Industry</bold> </p> </abstract>