Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population. Issue 2 (12th February 2013)

• Record Type: Journal Article
• Authors: Du, Jiangbo; Ji, Jian; Gao, Yong; Xu, Lin; Xu, Jing; Zhu, Chen; Gu, Haiyong; Jiang, Jie; Li, Huizhang; Ma, Hongxia; Hu, Zhibin; Jin, Guangfu; Guo, Wei; Chen, Xiaofei; Shen, Hongbing
• Is Part Of: International journal of cancer. Volume 133:Issue 2(2013:Jul. 15)
• Page Start: 357
• Page End: 361
• Publication Date: 2013-02-12
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.28033
• Languages: English
• ISSNs: 0020-7136

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>FAT4 plays a crucial role in carcinogenesis as a key component of the Hippo signaling pathway. We hypothesized that potential functional polymorphisms in the <italic>FAT4</italic> gene may modify the risk of esophageal cancer. To test this hypothesis, we evaluated the association between four nonsynonymous polymorphisms (rs1039808, rs12508222, rs1567047 and rs1014867) in <italic>FAT4</italic> and esophageal cancer risk in a case–control study of 2, 139 esophageal cancer cases and 2, 273 controls in a Chinese population. We found that the T allele of rs1014867 (Pro4972Ser) was significantly associated with a decreased risk of esophageal cancer (odds ratio [OR]=0.77, 95% confidence interval [95% CI]=0.66–0.90; <italic>p</italic>=1.42 × 10⁻³). We also observed a borderline significant association between rs1039808 (Ala807Val) and esophageal cancer risk (OR=0.90, 95% CI=0.82–1.00; <italic>p</italic>=0.050), which was more prominent in non‐drinkers (OR=0.82, 95% CI=0.71–0.94; <italic>p</italic>=6.53 × 10⁻³). Furthermore, we detected a significant interaction between rs1039808 genotypes and alcohol drinking on esophageal cancer risk (<italic>p</italic>=0.013). These findings indicate that the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of <italic>FAT4</italic> may contribute to esophageal cancer susceptibility.</p> </abstract>