Echocardiographic Evidence of Left Ventricular Hypertrophy in Obese Dogs. (29th November 2012)

• Record Type: Journal Article
• Authors: Mehlman, E.; Bright, J.M.; Jeckel, K.; Porsche, C.; Veeramachaneni, D.N.R.; Frye, M.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 1(2013:Jan./Feb.)
• Page Start: 62
• Page End: 68
• Publication Date: 2012-11-29
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12018
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12018-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12018-sec-0001" sec-type="section"> <title>Background</title> <p>Cardiomyopathy of obesity occurs in humans, but the gross and cellular myocardial response to obesity in dogs is not well defined.</p> </sec> <sec id="jvim12018-sec-0002" sec-type="section"> <title>Objectives</title> <p>To characterize in vivo myocardial morphology and function in normotensive obese dogs, and quantitate collagen, triglyceride and myocyte cross‐sectional area (CSA) in postmortem tissues from obese dogs.</p> </sec> <sec id="jvim12018-sec-0003" sec-type="section"> <title>Animals</title> <p>Echocardiographic‐Doppler measurements of normotensive obese dogs (n = 19) without historical or physical examination evidence of disease, and lean healthy dogs (n = 19) matched for age and ideal weight. Postmortem data were obtained from a separate population of 4 obese and 12 lean dogs without evidence of cardiac disease.</p> </sec> <sec id="jvim12018-sec-0004" sec-type="section"> <title>Methods</title> <p>A prospective, observational study of myocardial morphology and function was conducted by echocardiographic‐Doppler measurement. Left ventricular (LV) tissue was collected for quantitation of triglyceride, collagen, and myocyte CSA.</p> </sec> <sec id="jvim12018-sec-0005" sec-type="section"> <title>Results</title> <p>Compared with lean control dogs, obese dogs had increased systolic blood pressure (obese 153 ± 19 mm Hg; lean 133 ± 20 mm Hg; <italic>P</italic> = .003), and increased LV free wall thickness at end‐diastole (obese 9.9 ± 1.8 mm, lean 8.7 ± 1.5 mm; <italic>P</italic> = .03) and end‐systole (obese 15.2 ± 2.3 mm, lean 12.9 ± 2.3 mm; <italic>P</italic> = .004). Isovolumic relaxation time was prolonged in 7/19 (37%) of obese dogs, compared with normal ranges. Myocardial triglyceride and collagen content and myocyte CSA were similar between groups.</p> </sec> <sec id="jvim12018-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>As in humans, LV hypertrophy and diastolic dysfunction can be an early myocardial change in some obese dogs.</p> </sec> </abstract>