Radioligands for the dopamine receptor subtypes1. (24th April 2013)

• Record Type: Journal Article
• Authors: Prante, Olaf; Maschauer, Simone; Banerjee, Ashutosh
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 56:Number 3/4(2013)
• Page Start: 130
• Page End: 148
• Publication Date: 2013-04-24
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3000
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The actions of the predominant neurotransmitter in the brain, dopamine, are mediated by the postsynaptic dopamine receptors. The five dopamine receptor subtypes and their regulation have been associated with a large variety of psychiatric diseases. Therefore, positron emission tomography (PET) imaging studies using suitable and selective ¹⁸F‐labeled and ¹¹C‐labeled dopamine receptor radioligands could provide valuable knowledge on the impact of receptor density on the pathogenesis and evolvement of neuropsychiatric and neurological diseases. This special issue subchapter provides a summary of the most important ¹⁸F‐labeled and ¹¹C‐labeled radioligands for PET imaging of the dopamine receptor subtypes, their radiochemistry, and characteristics from <italic>in vitro</italic> and <italic>in vivo</italic> applications, considering not only the already established PET ligands but also the recently published preclinical work. Copyright © 2013 John Wiley &amp; Sons, Ltd.</p> </abstract>