Relationship between vitamin D status and left ventricular geometry in a healthy population: results from the Baltimore Longitudinal Study of Aging. (12th November 2012)

• Record Type: Journal Article
• Authors: Ameri, P.; Canepa, M.; Milaneschi, Y.; Spallarossa, P.; Leoncini, G.; Giallauria, F.; Strait, J. B.; Lakatta, E. G.; Brunelli, C.; Murialdo, G.; Ferrucci, L.
• Is Part Of: Journal of internal medicine. Volume 273:Number 3(2013:Mar.)
• Page Start: 253
• Page End: 262
• Publication Date: 2012-11-12
• Subjects: Internal medicine -- Periodicals; Medicine -- Periodicals; 616
• DOI: 10.1111/joim.12007
• Languages: English
• ISSNs: 0954-6820

Abstract

<abstract abstract-type="main" id="joim12007-abs-0001"> <title>Abstract</title> <sec id="joim12007-sec-0001" sec-type="section"> <title>Objectives</title> <p>The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community‐dwelling subjects without heart disease.</p> </sec> <sec id="joim12007-sec-0002" sec-type="section"> <title>Design</title> <p>The relationship between concentrations of 25‐hydroxyvitamin D [25(OH)D], a marker of vitamin D reserve, and LV transthoracic echocardiography measures was analysed in 711 participants in the Baltimore Longitudinal Study of Aging who were without cardiac disease.</p> </sec> <sec id="joim12007-sec-0003" sec-type="section"> <title>Results</title> <p>Mean 25(OH)D in the study population was 32.3 ± 11.4 ng mL<sup>−1</sup>; only 15.5% of subjects had moderate or severe vitamin D deficiency [25(OH)D < 20 ng mL<sup>−1</sup>]. Adjusting for age, body mass index, cardiovascular disease risk factors, physical activity, calcium and parathyroid hormone, 25(OH)D was positively correlated with LV thickness (β 0.095, SE 0.039, <italic>P </italic><<italic> </italic>0.05) and LV mass index (β 7.5, SE 2.6, <italic>P </italic><<italic> </italic>0.01). A significant nonlinear relation between 25(OH)D and LV concentric remodelling was observed. LV remodelling was more likely in participants with 25(OH)D levels <30 ng mL<sup>−1</sup> [odds ratio (OR) 1.24; 95% confidence interval (CI) 0.83–1.85] or ≥38 ng mL<sup>−1</sup> (OR 1.73; 95% CI 1.13–2.65), compared with those with 30–37 ng mL<sup>−1</sup> 25(OH)D. Consistently, LV relative wall thickness was significantly lower (<italic>P</italic> for trend=0.05), and LV diastolic internal diameter index (<italic>P</italic> for trend<0.05) and end‐diastolic volume index (<italic>P</italic> for trend<0.05) were significantly higher in subjects with 30–37 ng mL<sup>−1</sup> 25(OH)D compared to the rest of the study population. There was a significant interaction between 25(OH)D and hypertension on the risk of LV hypertrophy (<italic>P </italic><<italic> </italic>0.05).</p> </sec> <sec id="joim12007-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In a population‐based sample of predominantly vitamin D‐sufficient subjects without heart disease, LV geometry was most favourable at intermediate 25(OH)D concentrations.</p> </sec> </abstract>