Salivary markers of oxidative stress are related to age and oral health in adult non‐smokers. (14th September 2012)

• Record Type: Journal Article
• Authors: Celecová, Viera; Kamodyová, Natália; Tóthová, Ľubomíra; Kúdela, Matúš; Celec, Peter
• Is Part Of: Journal of oral pathology & medicine. Volume 42:Number 3(2013:Mar.)
• Page Start: 263
• Page End: 266
• Publication Date: 2012-09-14
• Subjects: Dentistry -- Periodicals; Teeth -- Diseases -- Periodicals; 617
• DOI: 10.1111/jop.12008
• Languages: English
• ISSNs: 0904-2512

Abstract

<abstract abstract-type="main" id="jop12008-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jop12008-sec-0001" sec-type="section"> <title>Background</title> <p>Salivary concentrations of thiobarbituric acid‐reacting substances (TBARS) are associated with the periodontal status assessed as papillary bleeding index (PBI). Whether this association is age independent is currently unclear. Salivary concentrations of advanced oxidation protein products (AOPPs) and advanced glycation end products (AGEs) have not been assessed in relation to age or oral health yet. The aim of our study was to analyse salivary markers of oxidative stress in dental patients in relation to age, gender and oral health.</p> </sec> <sec id="jop12008-sec-0002" sec-type="section"> <title>Methods</title> <p>Consecutive adult non‐smoking dental patients were enrolled (<italic>n</italic> = 204; aged 19–83 years). PBI and the caries index (CI) were assessed. Markers of oxidative stress, such as TBARS, AOPPs and AGEs, and the total antioxidant capacity (TAC) were measured in saliva samples taken before clinical examination.</p> </sec> <sec id="jop12008-sec-0003" sec-type="section"> <title>Results</title> <p>Linear regression showed that salivary TBARS, AGEs and TAC significantly increase with age (<italic>r</italic> squared = 5.3%, 2.1% and 5%, respectively). PBI is an independent predictor of salivary TBARS (<italic>r</italic> squared = 5.5%), and the CI negatively affected AOPPs (<italic>r</italic> = 3.2%) and positively affected TBARS (<italic>r</italic> = 2.5%). Gender did not affect any of the analysed parameters.</p> </sec> <sec id="jop12008-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Age as a significant contributor to the variance should be taken into account in studies focusing on salivary markers of oxidative stress. The relationship between PBI and salivary TBARS confirms results from previous studies. In addition, our results show that the association is age independent. Negative association between the CI and AOPPs might be related to recent findings that AOPP might be actually a marker of non‐enzymatic antioxidant status.</p> </sec> </abstract>