What Role for Store‐Operated Ca2+ Entry in Muscle?. (10th May 2013)

• Record Type: Journal Article
• Authors: Trebak, Mohamed; Zhang, Wei; Ruhle, Brian; Henkel, Matthew M.; González‐Cobos, José C.; Motiani, Rajender K.; Stolwijk, Judith A.; Newton, Rachel L.; Zhang, Xuexin
• Is Part Of: Microcirculation. Volume 20:Number 4(2013:May)
• Page Start: 330
• Page End: 336
• Publication Date: 2013-05-10
• Subjects: Biological transport -- Periodicals; Microcirculation -- Physiology -- Periodicals; 612.135
• DOI: 10.1111/micc.12042
• Languages: English
• ISSNs: 1073-9688

Abstract

<abstract abstract-type="main" xml:lang="en" id="micc12042-abs-0001"> <title>Abstract</title> <p>Store‐operated Ca<sup>2+</sup> entry (SOCE) is a receptor‐regulated Ca<sup>2+</sup> entry pathway that is both ubiquitous and evolutionarily conserved. SOCE is activated by depletion of intracellular Ca<sup>2+</sup> stores through receptor‐mediated production of inositol 1, 4, 5‐trisphosphate (IP<sub>3</sub>). The depletion of endoplasmic reticulum (ER) Ca<sup>2+</sup> is sensed by stromal interaction molecule 1 (STIM1). On store depletion, STIM1 aggregates and moves to areas where the ER comes close to the plasma membrane (PM; within 25 nm) to interact with Orai1 channels and activate Ca<sup>2+</sup> entry. Ca<sup>2+</sup> entry through store‐operated Ca<sup>2+</sup> (SOC) channels, originally thought to mediate the replenishment of Ca<sup>2+</sup> stores, participate in active downstream signaling by coupling to the activation of enzymes and transcription factors that control a wide variety of long‐term cell functions such as proliferation, growth, and migration. SOCE has also been proposed to contribute to short‐term cellular responses such as muscle contractility. While there are significant STIM1/Orai1 protein levels and SOCE activity in adult skeletal muscle, the precise role of SOCE in skeletal muscle contractility is not clear. The dependence on SOCE during cardiac and smooth muscle contractility is even less certain. Here, we will hypothesize on the contribution of SOCE in muscle and its potential role in contractility and signaling.</p> </abstract>