A convenient method to produce [14C]carbon monoxide and its application to the radiosynthesis of [carboxyl‐14C]celivarone, [carboxyl‐14C]SSR149744. (22nd January 2013)

• Record Type: Journal Article
• Authors: Whitehead, David M.; Hartmann, Sascha; Ilyas, Tenzeela; Taylor, Keith R.; Kohler, Andrew D.; Ellames, George J.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 56:Number 2(2013)
• Page Start: 36
• Page End: 41
• Publication Date: 2013-01-22
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3009
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>[<italic>carboxyl</italic>‐¹⁴C]Celivarone was synthesised from barium [¹⁴C]carbonate with overall radiochemical yields in the range 49–53%. The synthetic route involves [¹⁴C]carbonylation methodology, which both decreased the number of synthetic steps and increased the yields obtained from previous synthetic routes.</p> </abstract>