Potential food‐drug interactions in patients with rheumatoid arthritis. (18th June 2013)

• Record Type: Journal Article
• Authors: Masuko, Kayo; Tohma, Shigeto; Matsui, Toshihiro
• Is Part Of: International journal of rheumatic diseases. Volume 16:Number 2(2013)
• Page Start: 122
• Page End: 128
• Publication Date: 2013-06-18
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.12069
• Languages: English
• ISSNs: 1756-1841

Abstract

<abstract abstract-type="main" id="apl12069-abs-0001"> <title>Abstract</title> <p>Various medications are used for the treatment of rheumatoid arthritis (RA). Food–drug interactions may occur with concomitant ingestion of particular food. For example, methotrexate (MTX), the anchor drug in the therapeutic strategy against RA, is an antifolate agent. Excessive presence or absence of dietary folic acid may regulate MTX metabolism, possibly leading to unexpected adverse reactions. In this review, we focus on MTX, isoniazide and calcineurin inhibitors, and the implications of potential food–drug reactions in rheumatology, suggesting the important role of nutritional evaluations in RA patients.</p> </abstract>