Effect of maropitant, a neurokinin‐1 receptor antagonist, on the minimum alveolar concentration of sevoflurane during stimulation of the ovarian ligament in cats. (13th February 2013)

• Record Type: Journal Article
• Authors: Niyom, Sirirat; Boscan, Pedro; Twedt, David C; Monnet, Eric; Eickhoff, Jens C
• Is Part Of: Veterinary anaesthesia and analgesia. Volume 40:Number 4(2013:Jul.)
• Page Start: 425
• Page End: 431
• Publication Date: 2013-02-13
• Subjects: Veterinary anesthesia -- Periodicals; 636.089
• DOI: 10.1111/vaa.12017
• Languages: English
• ISSNs: 1467-2987

Abstract

<abstract abstract-type="main" xml:lang="en" id="vaa12017-abs-0001"> <title>Abstract</title> <sec id="vaa12017-sec-0001" sec-type="section"> <title>Objective</title> <p>Determine if maropitant decreases the minimum alveolar concentration (MAC) of sevoflurane during stimulation of the ovarian ligament in cats.</p> </sec> <sec id="vaa12017-sec-0002" sec-type="section"> <title>Study design</title> <p>Prospective study.</p> </sec> <sec id="vaa12017-sec-0003" sec-type="section"> <title>Animals</title> <p>Fifteen, female cats weighing 2.5 ± 0.6kg (mean ± SD).</p> </sec> <sec id="vaa12017-sec-0004" sec-type="section"> <title>Methods</title> <p>Anesthesia was induced and maintained with sevoflurane. The right ovary was accessed via laparoscopy. A suture around the ovary and ovarian ligament was exteriorized through the abdominal wall for stimulation. A stimulus–response curve was created to identify the optimal force for MAC comparisons. In 10 cats, MAC was determined with only sevoflurane (baseline) then after 1 and 5 mg kg<sup>−1</sup> intravenous maropitant administration. The stimulation tension force used was 4.9 N. Repeated measures <sc>anova</sc> was used to compare the groups. MAC was defined as the average of the cross‐over concentrations and reported MAC is adjusted to sea‐level and depicted as mean ± SD.</p> </sec> <sec id="vaa12017-sec-0005" sec-type="section"> <title>Results</title> <p>The stimulus‐response curve was hyperbolic and plateaued at 4.3 ± 3 N. The optimal tension force chosen to compare MAC was 4.9 N. The baseline sevoflurane MAC was 2.96 ± 0.3%. Maropitant, 1 mg kg<sup>−1</sup>, decreased the MAC to 2.51 ± 0.3% (15%, <italic>p </italic><<italic> </italic>0.01). The higher maropitant dose of 5 mg kg<sup>−1</sup> did not change MAC further when compared to the low dose (2.46 ± 0.4%, <italic>p </italic>=<italic> </italic>0.33).</p> </sec> <sec id="vaa12017-sec-0006" sec-type="section"> <title>Conclusion and clinical relevance</title> <p>The ovarian ligament stimulation model is suitable to determine MAC during visceral stimulation in cats. Maropitant decreased the anesthetic requirements during visceral ovarian and ovarian ligament stimulation in cats. Maropitant (1 mg kg<sup>−1</sup>) decreases MAC by 15%; a higher dose had no additional effect.</p> </sec> </abstract>