Follicular lymphoma in Taiwan: a low frequency of t(14;18), with grade 3A tumours more closely related to grade 3B than to low‐grade tumours. Issue 1 (30th April 2013)

• Record Type: Journal Article
• Authors: Chang, Sheng‐Tsung; Lu, Yi‐Hsuan; Lu, Chin‐Li; Kuo, Szu‐Yin; Liu, Hongxiang; Lin, Shu‐Hui; Win, Khin Than; Hsieh, Yen‐Chuan; Chuang, Shih‐Sung
• Is Part Of: Histopathology. Volume 63:Issue 1(2013)
• Page Start: 1
• Page End: 12
• Publication Date: 2013-04-30
• Subjects: Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.12119
• Languages: English
• ISSNs: 0309-0167

Abstract

<abstract abstract-type="main" id="his12119-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="his12119-sec-0001" sec-type="section"> <title>Aims</title> <p>To investigate t(14;18)/<italic>IGH–BCL2</italic> in follicular lymphoma (FL) cases from Taiwan.</p> </sec> <sec id="his12119-sec-0002" sec-type="section"> <title>Methods and results</title> <p>We retrospectively studied 93 consecutive cases, using immunohistochemistry and fluorescence <italic>in‐situ</italic> hybridization (FISH). Fifty‐nine (63%) tumours were low‐grade (LG) and 34 (37%) were high‐grade (HG; 24% FL3A and 13% FL3B). FISH showed <italic>IGH</italic>, <italic>BCL2</italic> and <italic>BCL6</italic> rearrangements in 59%, 47% and 11% of cases, respectively, and <italic>MYC</italic> rearrangement in 5% of FL3A tumours and 25% of FL3B tumours. The translocation partner of all <italic>BCL2</italic> rearrangements was <italic>IGH</italic>, with <italic>IGH–BCL2</italic> fusion in 63% of LG tumours and 18% of HG tumours. LG tumours were enriched with a CD10+/bcl‐2+/MUM1‐ phenotype, and were frequently associated with <italic>BCL2</italic> rearrangement but less commonly with <italic>BCL6</italic> rearrangement. FL3A tumours were more closely related to FL3B tumours than to LG tumours in immunophenotype and genetic aberrations. There was no statistically significant difference between grade 1 and two tumours, between FL3A and FL3B tumours or between nodal and extranodal tumours in immunophenotypic or FISH findings. The cumulative survival rate was higher in LG FL patients with <italic>IGH–BCL2</italic> translocation than in those without rearrangement.</p> </sec> <sec id="his12119-sec-0003" sec-type="section"> <title>Conclusions</title> <p>In Taiwan, FL3A tumours were more closely related to FL3B tumours than to LG tumours, and a literature review showed that the frequency of t(14;18)/<italic>IGH–BCL2</italic> in FL in Taiwan is among the lowest in the world.</p> </sec> </abstract>