A comparison of cardiopulmonary and anesthetic effects of an induction dose of alfaxalone or propofol in dogs. (19th January 2013)

• Record Type: Journal Article
• Authors: Maney, Jill K; Shepard, Molly K; Braun, Christina; Cremer, Jeannette; Hofmeister, Erik H
• Is Part Of: Veterinary anaesthesia and analgesia. Volume 40:Number 3(2013:May)
• Page Start: 237
• Page End: 244
• Publication Date: 2013-01-19
• Subjects: Veterinary anesthesia -- Periodicals; 636.089
• DOI: 10.1111/vaa.12006
• Languages: English
• ISSNs: 1467-2987

Abstract

<abstract abstract-type="main" xml:lang="en" id="vaa12006-abs-0001"> <title>Abstract</title> <sec id="vaa12006-sec-0001" sec-type="section"> <title>Objective</title> <p>To compare the physiological parameters, arterial blood gas values, induction quality, and recovery quality after IV injection of alfaxalone or propofol in dogs.</p> </sec> <sec id="vaa12006-sec-0002" sec-type="section"> <title>Study design</title> <p>Prospective, randomized, blinded crossover.</p> </sec> <sec id="vaa12006-sec-0003" sec-type="section"> <title>Animals</title> <p>Eight random‐source adult female mixed‐breed dogs weighing 18.7 ± 4.5 kg.</p> </sec> <sec id="vaa12006-sec-0004" sec-type="section"> <title>Methods</title> <p>Dogs were assigned to receive up to 8 mg kg<sup>−1</sup> propofol or 4 mg kg<sup>−1</sup> alfaxalone, administered to effect, at 10% of the calculated dose every 10 seconds. They then received the alternate drug after a 6‐day washout. Temperature, pulse rate, respiratory rate, direct blood pressure, and arterial blood gases were measured before induction, immediately post‐induction, and at 5‐minute intervals until extubation. Quality of induction, recovery, and ataxia were scored by a single blinded investigator. Duration of anesthesia and recovery, and adverse events were recorded.</p> </sec> <sec id="vaa12006-sec-0005" sec-type="section"> <title>Results</title> <p>The mean doses required for induction were 2.6 ± 0.4 mg kg<sup>−1</sup> alfaxalone and 5.2 ± 0.8 mg kg<sup>−1</sup> propofol. After alfaxalone, temperature, respiration, and pH were significantly lower, and PaCO<sub>2</sub> significantly higher post‐induction compared to baseline (<italic>p </italic><<italic> </italic>0.03). After propofol, pH, PaO<sub>2</sub>, and SaO<sub>2</sub> were significantly lower, and PaCO<sub>2</sub>, HCO<sub>3</sub>, and PA‐aO<sub>2</sub> gradient significantly higher post‐induction compared to baseline (<italic>p </italic>< 0.03). Post‐induction and 5‐minute physiologic and blood gas values were not significantly different between alfaxalone and propofol. Alfaxalone resulted in significantly longer times to achieve sternal recumbency (<italic>p</italic> = 0.0003) and standing (<italic>p</italic> = 0.0004) compared to propofol. Subjective scores for induction, recovery, and ataxia were not significantly different between treatments; however, dogs undergoing alfaxalone anesthesia were more likely to have ≥1 adverse event (<italic>p </italic>=<italic> </italic>0.041). There were no serious adverse events in either treatment.</p> </sec> <sec id="vaa12006-sec-0006" sec-type="section"> <title>Conclusions and clinical relevance</title> <p>There were no clinically significant differences in cardiopulmonary effects between propofol and alfaxalone. A single bolus of propofol resulted in shorter recovery times and fewer adverse events than a single bolus of alfaxalone.</p> </sec> </abstract>