Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis. (4th April 2012)

• Record Type: Journal Article
• Authors: Eom, Sung‐Hwan; Lee, Myung‐Suk; Lee, Eun‐Woo; Kim, Young‐Mog; Kim, Tae Hoon
• Is Part Of: Phytotherapy research. Volume 27:Number 1(2013:Jan.)
• Page Start: 148
• Page End: 151
• Publication Date: 2012-04-04
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.4694
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Pancreatic lipase is a potential therapeutic target for the treatment of diet‐induced obesity in humans. In an ongoing search for new pancreatic lipase inhibitors from natural sources, a methanolic extract of marine brown algae, <italic>Eisenia bicyclis</italic>, showed a significant inhibitory effect against pancreatic lipase. Bioassay‐guided isolation of this methanolic extract using a pancreatic lipase inhibitory assay led to the isolation and identification of six known phlorotannins: eckol (1), fucofuroeckol A (2), 7‐phloroeckol (3), dioxindehydroeckol (4), phlorofucofuroeckol A (5), and dieckol (6). The structures were established on the basis of nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Among the isolated phloroglucinol polymers, compounds 2 and 3 showed potent inhibitory effects on pancreatic lipase with IC₅₀ values ranging from 37.2 ± 2.3 to 12.7 ± 1.0 μM, respectively. Copyright © 2012 John Wiley &amp; Sons, Ltd.</p> </abstract>