Relationship between Endoscopic and Histologic Gastric Atrophy and Intestinal Metaplasia. Issue 2 (20th November 2012)

• Record Type: Journal Article
• Authors: Quach, Duc Trong; Le, Huy Minh; Hiyama, Toru; Nguyen, Oanh Thuy; Nguyen, Trung Sao; Uemura, Naomi
• Is Part Of: Helicobacter. Volume 18:Issue 2(2013:Apr.)
• Page Start: 151
• Page End: 157
• Publication Date: 2012-11-20
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12027
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" id="hel12027-abs-0001"> <title>Abstract</title> <sec id="hel12027-sec-0001" sec-type="section"> <title>Background</title> <p>The severity of endoscopic gastric atrophy (EGA), high‐stage Operative Link on Gastritis Assessment (OLGA) gastritis (i.e., stage III or IV), and extensive intestinal metaplasia (IM) with incomplete subtype have been separately reported as high‐risk factors of gastric cancer (GC). The aim of this study was to evaluate the associations between these endoscopic and pathologic characteristics.</p> </sec> <sec id="hel12027-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>A cross‐sectional study was conducted on 280 patients with functional dyspepsia at the University Medical Center at Ho Chi Minh City, Vietnam. Biopsies were taken according to the updated Sydney System. EGA was assessed according to the Kimura–Takemoto classification, and gastritis stage was assessed according to the OLGA system.</p> </sec> <sec id="hel12027-sec-0003" sec-type="section"> <title>Results</title> <p>All of patients with high‐stage OLGA gastritis (i.e., stage III or IV) clustered in the subgroup of patients with moderate‐to‐severe EGA: 13/126 (10.3%) in patients with moderate‐to‐severe EGA versus 0/154 (0%) in patients with none‐to‐mild EGA (<italic>p </italic><<italic> </italic>.001). Moderate‐to‐severe EGA was also significantly associated with extensive IM (<italic>p < </italic>.001, OR = 28.1 (CI 95% 6.4–173.3)) and incomplete IM subtype (<italic>p </italic><<italic> </italic>.001, OR = 36.7 (CI 95% 5.1–742.1). Extensive IM was also associated with incomplete IM subtype (<italic>p </italic>=<italic> </italic>.01).</p> </sec> <sec id="hel12027-sec-0004" sec-type="section"> <title>Conclusions</title> <p>High‐stage OLGA gastritis, extensive IM with incomplete subtype clustered in patients with moderate‐to‐severe EGA. Assessing the severity of EGA could potentially help to identify patients who should be taken systemic biopsy for evaluating GC risk.</p> </sec> </abstract>