Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients. (24th September 2012)

• Record Type: Journal Article
• Authors: Erciyas, K; Sezer, U; Üstün, K; Pehlivan, Y; Kısacık, B; Şenyurt, SZ; Tarakçıoğlu, M; Onat, AM
• Is Part Of: Oral diseases. Volume 19:Number 4(2013:May)
• Page Start: 394
• Page End: 400
• Publication Date: 2012-09-24
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12017
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12017-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12017-sec-0001" sec-type="section"> <title>Objective</title> <p>This observational prospective cohort study aimed to evaluate the effects of non‐surgical periodontal treatment on clinical periodontal measurements and systemic inflammatory mediator levels in low or moderate to highly active rheumatoid arthritis (RA) patients with chronic periodontitis.</p> </sec> <sec id="odi12017-sec-0002" sec-type="section"> <title>Subjects and methods</title> <p>Rheumatoid arthritis activity was assessed with disease activity score test (DAS28). Thirty patients with RA with moderate to high disease activity (DAS28 ≥ 3.2) and chronic periodontitis (MHDA group) and thirty patients with RA with low disease activity (DAS28 < 3.2) and chronic periodontitis (LDA group) were enrolled in the study. The patients were monitored at the beginning and 3 months after undergoing periodontal therapy. Erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), tumour necrosis factor‐alpha (TNF‐α) levels in serum, DAS28 and periodontal parameters were evaluated.</p> </sec> <sec id="odi12017-sec-0003" sec-type="section"> <title>Results</title> <p>Erythrocyte sedimentation rate, CRP, TNF‐α levels in serum, DAS28 and periodontal parameters exhibited similar and significant reduction 3 months after the non‐surgical periodontal treatment.</p> </sec> <sec id="odi12017-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Non‐surgical periodontal treatment may prove beneficial in reducing RA severity as measured by ESR, CRP, TNF‐α levels in serum and DAS28 in low or moderate to highly active RA patients with chronic periodontitis.</p> </sec> </abstract>