Gingival advanced glycation end‐products in diabetes mellitus‐associated chronic periodontitis: an immunohistochemical study. (28th September 2012)

• Record Type: Journal Article
• Authors: Zizzi, A.; Tirabassi, G.; Aspriello, S. D.; Piemontese, M.; Rubini, C.; Lucarini, G.
• Is Part Of: Journal of periodontal research. Volume 48:Number 3(2013:Jun.)
• Page Start: 293
• Page End: 301
• Publication Date: 2012-09-28
• Subjects: Periodontics -- Periodicals; 617.632
• DOI: 10.1111/jre.12007
• Languages: English
• ISSNs: 0022-3484

Abstract

<abstract abstract-type="main" id="jre12007-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jre12007-sec-0001" sec-type="section"> <title>Background and Objective</title> <p>The accumulation of advanced glycation end‐products (AGEs) seems to play an important role in the development of diabetes mellitus (DM)‐associated periodontitis; however, some aspects of this issue are still scarcely known, such as the expression of AGEs in type 1 DM‐associated periodontitis and the clinical factors able to affect their accumulation. This study aimed to clarify these points by evaluating the expression of AGEs in DM‐associated periodontitis.</p> </sec> <sec id="jre12007-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Sixteen systemically and periodontally healthy subjects and 48 subjects suffering from generalized, severe, chronic periodontitis (16 with type 1 DM, 16 with type 2 DM and 16 systemically healthy subjects) were studied clinically, periodontally and metabolically. The immunohistochemical expression of AGEs in gingival tissues was also evaluated.</p> </sec> <sec id="jre12007-sec-0003" sec-type="section"> <title>Results</title> <p>Subjects affected with type 1 DM presented a significantly higher percentage of AGE‐positive cells than did subjects affected with type 2 DM, not only in the epithelium, but also in vessels and fibroblasts. A positive and significant correlation was found between gingival expression of AGEs and length of time affected with DM both in type 1 and type 2 DM; glycated hemoglobin, lipid profile, body mass index and age did not correlate significantly with gingival AGEs in any of the classes of subjects studied.</p> </sec> <sec id="jre12007-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Gingival AGEs are increased in both type 1 and type 2 DM‐associated periodontitis; however, the clinical parameter that determines their accumulation, and therefore their degree of influence on the development of DM‐associated periodontitis, may be the duration of DM.</p> </sec> </abstract>