Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation. (5th November 2012)

• Record Type: Journal Article
• Authors: Sprinzl, Martin F.; Weinmann, Arndt; Lohse, Nikola; Tönissen, Hanna; Koch, Sandra; Schattenberg, Jörn; Hoppe‐Lotichius, Maria; Zimmermann, Tim; Galle, Peter R.; Hansen, Torsten; Otto, Gerd; Schuchmann, Marcus
• Is Part Of: Transplant international. Volume 26:Number 1(2013:Jan.)
• Page Start: 67
• Page End: 74
• Publication Date: 2012-11-05
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/j.1432-2277.2012.01576.x
• Languages: English
• ISSNs: 0934-0874

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Summary</title> <p>The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS‐associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. <italic>De novo</italic> MetS affected 32.9% of our cohort (<italic>n </italic>= 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels ≥5% [odds ratio (OR)<italic> </italic>= 3.5; 95% confidence interval (CI)<italic> </italic>= 1.56–8.13, <italic>P </italic>= 0.003], diabetes mellitus (OR<italic> </italic>= 4.31, CI<italic> </italic>= 1.69–10.99, <italic>P </italic>= 0.002), and arterial hypertension (OR<italic> </italic>= 4.59, CI<italic> </italic>= 1.46–14.49, <italic>P </italic>= 0.009) as independent risk factors for <italic>de novo</italic> MetS. MetS incidence correlated with steroid dosage after OLT (5.2 ± 2.4 mg/day vs. 7.1 ± 4.7 mg/day, <italic>P </italic>= 0.014), and was linked to NAFLD (<italic>P = </italic>0.001) via obesity (OR<italic> </italic>= 4.67, CI<italic> </italic>= 1.55–14.1, <italic>P </italic>= 0.006) and dyslipidemia (OR<italic> </italic>= 4.23, CI<italic> </italic>= 1.35–13.3, <italic>P </italic>=<italic> </italic>0.013) post‐OLT. In conclusion, we were able to identify low threshold HbA1c as a novel risk factor for MetS after OLT and described a link of MetS with NAFLD in transplant organs. This study also indicated that steroid treatment is associated with MetS rates after OLT.</p> </abstract>