Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non‐hispanic white women: The breast cancer health disparities study. Issue 12 (13th December 2012)

• Record Type: Journal Article
• Authors: Slattery, Martha L.; John, Esther M.; Torres‐Mejia, Gabriela; Herrick, Jennifer S.; Giuliano, Anna R.; Baumgartner, Kathy B.; Hines, Lisa M.; Wolff, Roger K.
• Is Part Of: International journal of cancer. Volume 132:Issue 12(2013:Jun. 15)
• Page Start: 2928
• Page End: 2939
• Publication Date: 2012-12-13
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.27960
• Languages: English
• ISSNs: 0020-7136

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Bone morphogenetic proteins (BMP) are thought to be important in breast cancer promotion and progression. We evaluated genetic variation in BMP‐related genes and breast cancer risk among Hispanic (2, 111 cases, 2, 597 controls) and non‐Hispanic White (NHW) (1, 481 cases, 1, 586 controls) women who participated in the 4‐Corner's Breast Cancer Study, the Mexico Breast Cancer Study and the San Francisco Bay Area Breast Cancer Study. BMP genes and their receptors evaluated include <italic>ACVR1</italic>, <italic>AVCR2A</italic>, <italic>ACVR2B</italic>, <italic>ACVRL1</italic>, <italic>BMP1</italic>, <italic>BMP2</italic>, <italic>BMP4</italic>, <italic>BMP6</italic>, <italic>BMP7</italic>, <italic>BMPR1A</italic>, <italic>BMPR1B, BMPR2</italic>, <italic>MSTN</italic> and <italic>GDF10</italic>. Additionally, 104 ancestral informative markers were assessed to discriminate between European and native American ancestry. The importance of estrogen on BMP‐related associations was suggested through unique associations by menopausal status and estrogen (ER) and progesterone (PR) receptor status of tumors. After adjustment for multiple comparisons <italic>ACVR1</italic> (8 SNPs) was modestly associated with ER+PR+ tumors [odds ratios (ORs) between 1.18 and 1.39 <italic>p</italic><sub>adj</sub> < 0.05]. <italic>ACVR1</italic> (3 SNPs) and <italic>BMP4</italic> (3 SNPs) were associated with ER+PR− tumors (ORs 0.59–2.07; <italic>p</italic><sub>adj</sub> < 0.05). <italic>BMPR2</italic> was associated with ER−PR+ tumors (OR 4.20; 95% CI 1.62, 10.91; <italic>p</italic><sub>adj</sub> < 0.05) as was <italic>GDF10</italic> (2 SNPs; ORs 3.62 and 3.85; <italic>p</italic><sub>adj</sub> < 0.05). After adjustment for multiple comparisons several SNPs remained associated with ER−PR− tumors (<italic>p</italic><sub>adj</sub> < 0.05) including <italic>ACVR1</italic><italic>BMP4</italic> and <italic>GDF10</italic> (ORs between 0.53 and 2.12). Differences in association also were observed by percentage of native ancestry and menopausal status. Results support the hypothesis that genetic variation in BMPs is associated with breast cancer in this admixed population.</p> </abstract>