Adsorption mode of neurotensin family peptides onto a colloidal silver surface: SERS studies. (21st November 2012)

• Record Type: Journal Article
• Authors: Proniewicz, Edyta; Ozaki, Yukihiro; Kim, Younkyoo; Proniewicz, Leonard M.
• Is Part Of: Journal of Raman spectroscopy. Volume 44:Number 3(2013:Mar.)
• Page Start: 355
• Page End: 361
• Publication Date: 2012-11-21
• Subjects: Raman spectroscopy -- Periodicals; 535.846
• DOI: 10.1002/jrs.4207
• Languages: English
• ISSNs: 0377-0486

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Kinetensin (KN) and its amino acids 1–8 fragment ([des‐Leu⁹]KN), neuromedin N (NMN), and xenopsin (XP) and its two analogs (human XP‐1/xenin‐8 and XP‐2) belong to the neurotensin family of peptides and are known to stimulate the growth of human tumors. In this work, we report surface‐enhanced Raman scattering (SERS) studies of these peptides and discuss their structures, orientation, and mode of adsorption onto a colloidal assembly of apparently randomly adhering Ag spheres with diameters of approximately 20 – 25 nm. We show that small alternations in both the amino acid composition and tertiary structure, which induce striking biological <italic>in vitro</italic>, were responsible for the observed spectroscopic changes. Copyright © 2012 John Wiley &amp; Sons, Ltd.</p> </abstract>