Association of midtrimester short femur and short humerus with fetal growth restriction. (28th November 2012)

• Record Type: Journal Article
• Authors: de, Ana Alice Vidal; Carvalho, José Antônio; Figueiredo, Israel; Velarde, Luis Guillermo Coca; Marchiori, Edson
• Is Part Of: Prenatal diagnosis. Volume 33:Number 2(2013:Feb.)
• Page Start: 130
• Page End: 133
• Publication Date: 2012-11-28
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4020
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="pd4020-sec-0001" sec-type="section"> <title>Objective</title> <p>To investigate the association between the midtrimester presence of short femur and short humerus and intrauterine growth restriction.</p> </sec> <sec id="pd4020-sec-0002" sec-type="section"> <title>Methods</title> <p>This retrospective study included ultrasound examinations of 1043 fetuses. Fetuses with normal‐length bones were compared with fetuses that had femoral or humeral lengths below the 5<sup>th</sup> percentile for gestational age by Student's <italic>t</italic>‐test and the chi‐squared test. The association between short bones and fetal growth restriction development was evaluated by Fisher's exact test. Fetuses with estimated weight below the 10<sup>th</sup> percentile for gestational age and abnormal umbilical artery flow were considered to have growth restriction.</p> </sec> <sec id="pd4020-sec-0003" sec-type="section"> <title>Results</title> <p>Femoral and humeral lengths were normal in 974 (93.4%) fetuses; 19 (1.8%) fetuses had short femora, 65 (6.2%) had short humeri, and 15 (1.4%) had short femora and humeri combined. Of fetuses included in the analysis, 603 (57.8%) underwent Doppler examination. Short femur [odds ratio = 9.7, 95% confidence interval = 1.9–50.2, <italic>P</italic> = 0.03] and short humerus (odds ratio = 13, 95% confidence interval = 4.9–34.6, <italic>P</italic> < 0.001) were associated with fetal growth restriction.</p> </sec> <sec id="pd4020-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Fetuses with midtrimester short femur, short humerus, or short femur and humerus combined require more intensive surveillance for growth restriction development. © 2012 John Wiley & Sons, Ltd.</p> </sec> </abstract>