Beta and alpha cell function in metabolically healthy but obese subjects: Relationship with entero‐insular axis1. (26th March 2013)

• Record Type: Journal Article
• Authors: Calanna, Salvatore; Piro, Salvatore; Di Pino, Antonino; Maria Zagami, Rose; Urbano, Francesca; Purrello, Francesco; Maria Rabuazzo, Agata
• Is Part Of: Obesity. Volume 21:Number 2(2013:Feb.)
• Page Start: 320
• Page End: 325
• Publication Date: 2013-03-26
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20017
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="abs1-1" sec-type="section"> <title>Objective:</title> <p>Obesity is widely acknowledged as a critical risk factor for metabolic complications. Among obese subjects, there is a phenotype of metabolically healthy but obese (MHO) individuals that shows a favorable cardiometabolic risk profile. We aimed to evaluate the potential mechanisms underlying the metabolic profile of this subset, including alpha and beta cell function and entero‐insular axis.</p> </sec> <sec id="abs1-2" sec-type="section"> <title>Design and Methods:</title> <p>One hundred twenty‐nine obese and 24 nonobese subjects were studied. Obese participants were defined as MHO or at‐risk obese, according to the homeostasis model of assessment‐insulin resistance (HOMA‐IR) index (MHO: lower tertile of HOMA‐IR, <italic>n</italic> = 43; at‐risk: upper tertile of HOMA‐IR index, <italic>n</italic> = 41). Insulin, glucagon, and incretin responses after a 120′ oral glucose tolerance test (75‐g OGTT) were investigated.</p> </sec> <sec id="abs1-3" sec-type="section"> <title>Results:</title> <p>During OGTT, MHO individuals showed in comparison with at‐risk subjects: lower fasting and afterloads plasma levels of glucose, insulin, and C‐peptide; higher disposition index; lower fasting (<italic>P</italic> = 0.004) and at 30′ (<italic>P</italic> = 0.01) plasma glucose‐dependent insulinotropic polypeptide (GIP) levels; lower area under the curve (AUC) (0‐30) for GIP (<italic>P</italic> = 0.008); higher glucagon‐like peptide‐1 (GLP‐1) plasma levels at 90′ (<italic>P</italic> = 0.02) and 120′ (<italic>P</italic> = 0.02); lower glucagon plasma levels at baseline (<italic>P</italic> = 0.04) and at 30′ (<italic>P</italic> = 0.03); and appropriate glucagon suppression after the oral glucose load.</p> </sec> <sec id="abs1-4" sec-type="section"> <title>Conclusions:</title> <p>MHO subjects show, as well as normal‐weight individuals, a lower diabetogenic profile by virtue of higher disposition index and unaffected entero‐insular axis. At‐risk obese individuals present increased GIP levels that might play a role in determining increased glucagon secretion and inappropriate glucagon responses after glucose load, thus contributing to impaired glucose homeostasis.</p> </sec> </abstract>