Intrapatient emergence of OXA‐247: a novel carbapenemase found in a patient previously infected with OXA‐163‐producing Klebsiella pneumoniae. (12th February 2013)

• Record Type: Journal Article
• Authors: Gomez, S.; Pasteran, F.; Faccone, D.; Bettiol, M.; Veliz, O.; De, D.; Rapoport, M.; Gatti, B.; Petroni, A.; Corso, A.; Cantón, R.
• Is Part Of: Clinical microbiology and infection. Volume 19:Number 5(2013:May)
• Page Start: E233
• Page End: E235
• Publication Date: 2013-02-12
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12142
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" xml:lang="en" id="clm12142-abs-0001"> <title>Abstract</title> <p>Two genetically related <italic>Klebsiella pneumoniae</italic> strains carrying OXA‐type carbapenemases were isolated from a single patient 1 month apart. Kpn163 harboured OXA‐163 and Kpn247 a new variant named OXA‐247 that showed susceptibility to carbapenems and expanded‐spectrum cephalosporins similar to OXA‐48. Our epidemiological, biochemical and molecular results suggest the intrapatient emergence of <italic>bla</italic>_OXA_‐247 from <italic>bla</italic>_OXA_‐163.</p> </abstract>