Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin‐15. Issue 4 (11th March 2013)

• Record Type: Journal Article
• Authors: Cairo, Cristiana; Sagnia, Bertrand; Cappelli, Giulia; Colizzi, Vittorio; Leke, Rose G. F.; Leke, Robert J.; Pauza, C. David
• Is Part Of: Immunology. Volume 138:Issue 4(2013:Apr.)
• Page Start: 346
• Page End: 360
• Publication Date: 2013-03-11
• Subjects: Immunology -- Periodicals
• DOI: 10.1111/imm.12039
• Languages: English
• ISSNs: 0019-2805

Abstract

<abstract abstract-type="main" xml:lang="en" id="imm12039-abs-0001"> <title>Summary</title> <p>Compared with adults, the circulating Vγ2Vδ2 T‐cell population in cord blood is present at low levels and does not show the strong bias for Vγ2‐Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T‐cell‐derived interleukin‐2 (IL‐2) or both. In cord blood mononuclear cell cultures, a single round of stimulation, using aminobisphosphonates to elevate phosphoantigen levels, resulted in expansion of adult‐like Vγ2 chains and accumulation of memory cells with cytotoxic potential. Selection was similar using IL‐2 or myeloid‐derived IL‐15. The Vγ2Vδ2 T cells present in neonates are capable of generating potent immune responses even when relying on IL‐15.</p> </abstract>