Carbon dioxide insufflation safety in double‐balloon enteroscopy: An experimental animal study. Issue 1 (26th April 2012)

• Record Type: Journal Article
• Authors: Soria, Federico; Lopez‐Albors, Octavio; Morcillo, Esther; Martin, Carolina; Sarria, Ricardo; Esteban, Pilar; Carballo, Fernando; Perez‐Cuadrado, Enrique; Sanchez, Francisco M; Latorre, Rafael
• Is Part Of: Digestive endoscopy. Volume 25:Issue 1(2013:Jan.)
• Page Start: 39
• Page End: 46
• Publication Date: 2012-04-26
• Subjects: Digestive organs -- Diseases -- Periodicals; Digestive organs -- Diseases -- Diagnosis -- Periodicals; Endoscopy -- Periodicals; Digestive System Diseases -- diagnosis -- Periodicals; Digestive System Diseases -- therapy -- Periodicals; Endoscopy -- Periodicals; 616.3
• DOI: 10.1111/j.1443-1661.2012.01320.x
• Languages: English
• ISSNs: 0915-5635

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="den1320-sec-0001" sec-type="section"> <title>Aim</title> <p>The aim of the present study was to assess the safety and efficacy of CO<sub>2</sub> during double‐balloon enteroscopy (DBE) in an experimental animal model study. In this study, insufflation with room air and with CO<sub>2</sub> was compared.</p> </sec> <sec id="den1320-sec-0002" sec-type="section"> <title>Methods</title> <p>Twenty healthy swines were used. The animals were randomly allocated to two groups. The room air‐DBE group was insufflated with room air, whereas the CO<sub>2</sub>‐DBE group was insufflated with CO<sub>2</sub>. Endoscopy duration was 90 min. The following parameters were measured during the study (basal, 30 min, 60 min, 90 min): invasive hemodynamic parameters, ventilatory parameters, arterial blood gases, exploration depth, as well as biochemical tests. Residual gas was evaluated at the end of DBE, at 180 min and 24 h after DBE.</p> </sec> <sec id="den1320-sec-0003" sec-type="section"> <title>Results</title> <p>During the endoscopic exploration none of the animals showed hemodynamic, ventilatory or arterial blood gas alterations in the normal reference range for the swine species. The CO<sub>2</sub> group showed statistically significant differences over the room air group with lower post‐procedure residual gas and greater depth of the small bowel explored.</p> </sec> <sec id="den1320-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The use of CO<sub>2</sub> for insufflation during DBE was safe and no complications associated with CO<sub>2</sub> were observed. In addition, the use of CO<sub>2</sub> offers benefits over the use of room air for insufflation during DBE.</p> </sec> </abstract>