Oxidized LDL Receptor 1 gene polymorphism in patients with Metabolic Syndrome. (7th November 2012)

• Record Type: Journal Article
• Authors: Palmieri, Vincenzo O.; Coppola, Brigida; Grattagliano, Ignazio; Casieri, Valentina; Cardinale, Giovanna; Portincasa, Piero; Palasciano, Giuseppe; Di Serio, Francesca
• Is Part Of: European journal of clinical investigation. Volume 43:Number 1(2013:Jan.)
• Page Start: 41
• Page End: 48
• Publication Date: 2012-11-07
• Subjects: Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.12013
• Languages: English
• ISSNs: 0014-2972

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="sec-sum-1" sec-type="section"> <p>Eur J Clin Invest 2012</p> </sec> <sec id="abs1-1" sec-type="section"> <title>Abstract</title> <p> <bold>Aims </bold> The lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis. We therefore evaluated the genotyping of OLR1 gene in a sample of 55 patients with Metabolic Syndrome, a clinical condition characterized by a high cardiovascular risk.</p> <p> <bold>Methods and Patients </bold> The genotyping of the LOX‐1 was performed by polymerase chain reaction (PCR) analysis of the IVS4‐14 A>G OLR1 polymorphism embedded within the OLR1 Linkage Disequilibrium block. Patients were assessed for routine serum parameters, microalbuminuria, insulin resistance (HOMA) and oxidative stress (thiobarbituric acid reactive substances, TBARs and thioredoxin).</p> <p> <bold>Results </bold> The allele or genotype distribution of the OLR1 IVS4‐14 A>G was not statistically different between MS and controls subjects. A positive association was found between IVS4‐14 GG genotype, microalbuminuria and fasting glycaemia as well as a higher frequency of type 2 diabetes, elevated microalbuminuria, fasting serum glucose and HOMA index in the same subjects. Thioredoxin values were higher in patients with MS but did not differ in relation to OLR1 IVS4‐14 A>G genotype. The TBARs/Cholesterol ratio was higher in MS both in IVS4‐14 GG and in IVS4‐14 AG.</p> <p> <bold>Conclusion </bold> IVS4‐14 GG genotype seems to be related to glucose metabolism disturbance, elevated insulin level and lipid peroxidation in patients with MS.</p> </sec> </abstract>