Characterisation of changes in the haemostasis system in dogs with thrombosis. (4th March 2013)

• Record Type: Journal Article
• Authors: Bauer, N.; Moritz, A.
• Is Part Of: Journal of small animal practice. Volume 54:Number 3(2013:Mar.)
• Page Start: 129
• Page End: 136
• Publication Date: 2013-03-04
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12037
• Languages: English
• ISSNs: 0022-4510

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jsap12037-sec-0001" sec-type="section"> <title>Objective</title> <p> <bold>To prospectively assess (2008 to 2009) all phases of coagulation including thromboelastography in dogs with thrombosis to determine if thrombosis is associated with hypercoagulable states.</bold> </p> </sec> <sec id="jsap12037-sec-0019" sec-type="section"> <title>Methods</title> <p> <bold>Coagulation reaction in dogs with thrombosis (n = 7) diagnosed by diagnostic imaging or histopathology was compared with 56 control dogs. Dogs pretreated with antiplatelet and anticoagulation drugs were excluded. Thromboelastographic G‐values >10 · 3 Kdyn/cm<sup>2</sup> were used to define a hypercoagulable state.</bold> </p> </sec> <sec id="jsap12037-sec-0002" sec-type="section"> <title>Results</title> <p> <bold>Compared with the controls, there was a significantly higher mean platelet component indicating lower platelet activation status (17 · 99 ±1 · 36 <italic>versus</italic> 20 · 48 ±2 · 04 g/dL, P = 0 · 0004), increased thromboelastographic G‐value (6 · 4 ±1 · 6 <italic>versus</italic> 13 · 1 ±6 · 2 Kdyn/cm<sup>2</sup>, P = 0 · 0029), activated partial thromboplastin time, fibrinogen, D‐dimers (all: P < 0 · 0001) as well as decreased antithrombin (P = 0 · 0049), factor VIII (P < 0 · 0001), protein C (P < 0 · 0001), protein S (P = 0 · 0373) and activated protein C‐ratio (P = 0 · 0013). On the basis of thromboelastographic G‐value, three of six thromboelastographic tracings were classified as normocoagulable and three as hypercoagulable.</bold> </p> </sec> <sec id="jsap12037-sec-0003" sec-type="section"> <title>Clinical Relevance</title> <p> <bold>In dogs with thrombosis, both normo‐ and hypercoagulable states are present and activated protein C resistance is common.</bold> </p> </sec> </abstract>