Innate immune responses against Cryptosporidium parvum infection. (9th January 2013)

• Record Type: Journal Article
• Authors: McDonald, V.; Korbel, D.S.; Barakat, F.M.; Choudhry, N.; Petry, F.
• Is Part Of: Parasite immunology. Volume 35:Number 2(2013:Feb.)
• Page Start: 55
• Page End: 64
• Publication Date: 2013-01-09
• Subjects: Veterinary parasitology -- Immunological aspects -- Periodicals; Host-parasite relationships -- Immunological aspects -- Periodicals; 571.96
• DOI: 10.1111/pim.12020
• Languages: English
• ISSNs: 0141-9838

Abstract

<abstract abstract-type="main" xml:lang="en" id="pim001-abs-0001"> <title>Summary</title> <p> <italic>Cryptosporidium parvum</italic> infects intestinal epithelial cells and is commonly the parasite species involved in mammalian cryptosporidiosis, a major health problem for humans and neonatal livestock. In mice, immunologically mediated elimination of <italic>C. parvum</italic> requires CD4⁺ T cells and IFN‐γ. However, innate immune responses also have a significant protective role in both adult and neonatal mice. NK cells and IFN‐γ have been shown to be important components in immunity in T and B cell‐deficient mice, but IFN‐γ‐dependent resistance has also been demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate antimicrobial killing mechanisms, including production of NO and antimicrobial peptides. Toll‐like receptors facilitate the establishment of immunity in mice and are involved in the development of inflammatory responses of infected epithelial cells and also dendritic cells.</p> </abstract>