Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide. (31st May 2011)

• Record Type: Journal Article
• Authors: Tong, Philip L; Walker, William A; Glancy, Ross J; Cooney, Julian P; Gebauer, Kurt
• Is Part Of: Australasian journal of dermatology. Volume 54:Number 1(2013:Feb.)
• Page Start: e12
• Page End: e15
• Publication Date: 2011-05-31
• Subjects: Dermatology -- Periodicals; Dermatology -- Australasia -- Periodicals; 616.5005
• DOI: 10.1111/j.1440-0960.2011.00770.x
• Languages: English
• ISSNs: 0004-8380

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <p>Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of localized cutaneous amyloidosis and can be associated with various connective tissue disorders. It can be difficult to treat and past therapies include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy and laser therapy. We present a case of a middle‐aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. It is important to monitor these patients for progression into systemic amyloidosis.</p> </abstract>