Comparison of the efficacy of ramosetron and ondansetron in the prophylaxis of postoperative vomiting in children receiving fentanyl by patient‐controlled analgesia after orthopedic surgery: a randomized controlled trial. Issue 4 (2nd January 2013)

• Record Type: Journal Article
• Authors: Park, Yong‐Hee; Jang, Young‐Eun; Byon, Hyo‐Jin; Kim, Jin‐Tae; Kim, Hee‐Soo; Lerman, Jerrold
• Is Part Of: Paediatric anaesthesia. Volume 23:Issue 4(2013)
• Page Start: 360
• Page End: 364
• Publication Date: 2013-01-02
• Subjects: Pediatric anesthesia -- Periodicals; 617.96798
• DOI: 10.1111/pan.12103
• Languages: English
• ISSNs: 1155-5645

Abstract

<abstract abstract-type="main" xml:lang="en" id="pan12103-abs-0001"> <title>Summary</title> <sec id="pan12103-sec-0001" sec-type="section"> <title>Background</title> <p>This study was designed to compare the efficacy of prophylactic ramosetron and ondansetron in preventing postoperative vomiting in children who received fentanyl by patient‐controlled analgesia after orthopedic surgery.</p> </sec> <sec id="pan12103-sec-0002" sec-type="section"> <title>Methods</title> <p>Two hundred and eighteen children, 2–15 years old, ASA physical status 1 or 2, scheduled for elective orthopedic surgeries, were randomly divided into the ramosetron group (<italic>n</italic> = 109) or ondansetron group (<italic>n</italic> = 109). Patients in ondansetron group received ondansetron 100 μg·kg<sup>−1</sup> and patients in ramosetron group received ramosetron 6 μg·kg<sup>−1</sup> after surgery. Intravenous patient‐controlled analgesia with fentanyl was used in both groups. The incidence of postoperative vomiting and side effects were assessed during the 48 h after surgery.</p> </sec> <sec id="pan12103-sec-0003" sec-type="section"> <title>Results</title> <p>There was significantly less vomiting during the first 24‐h and 6–24‐h period after surgery in ramosetron group than in ondansetron group (<italic>P</italic> < 0.01). There were no significant differences in side effect of 5‐HT<sup>3</sup> antagonist between the two groups.</p> </sec> <sec id="pan12103-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Ramosetron was more effective during the first 24‐h period after surgery than ondansetron in children using fentanyl patient‐controlled analgesia after general anesthesia.</p> </sec> </abstract>