Aryl‐Heteroaryl Derivatives as Novel Wake‐Promoting Agents. (26th December 2012)

• Record Type: Journal Article
• Authors: Lesur, Brigitte; Lin, Yin G.; Marcy, Val R.; Aimone, Lisa D.; Gruner, John; Bacon, Edward R.; Chatterjee, Sankar
• Is Part Of: Chemical biology & drug design. Volume 81:Number 3(2013:Mar.)
• Page Start: 429
• Page End: 432
• Publication Date: 2012-12-26
• Subjects: Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.12083
• Languages: English
• ISSNs: 1747-0277

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In search of a next generation molecule to the novel wake‐promoting agent modafinil, a series of aryl‐heteroayl‐derived wakefulness enhancing agents (in rats) was developed. From this work, compound <bold>16</bold> was separated into its enantiomers to profile them individually.</p> </abstract>