Long‐term Follow‐up Helicobacter Pylori Reinfection Rate and Its Associated Factors in Korea. Issue 2 (8th October 2012)

• Record Type: Journal Article
• Authors: Kim, Min Soo; Kim, Nayoung; Kim, Sung Eun; Jo, Hyun Jin; Shin, Cheol Min; Lee, Sang Hyub; Park, Young Soo; Hwang, Jin‐Hyeok; Kim, Jin‐Wook; Jeong, Sook‐Hyang; Lee, Dong Ho; Kim, Jung Mogg; Jung, Hyun Chae
• Is Part Of: Helicobacter. Volume 18:Issue 2(2013:Apr.)
• Page Start: 135
• Page End: 142
• Publication Date: 2012-10-08
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12018
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" xml:lang="en" id="hel12018-abs-0001"> <title>Abstract</title> <sec id="hel12018-sec-0001" sec-type="section"> <title>Background</title> <p>The reinfection rate of <italic>Helicobacter pylori</italic> has been reported to be low in developed countries but high in developing countries. The aim of this study is to evaluate the long‐term reinfection rate of <italic>H. pylori</italic> and to investigate its associated risk factors in South Korea.</p> </sec> <sec id="hel12018-sec-0002" sec-type="section"> <title>Methods</title> <p>During 2003–2010, <italic>H. pylori</italic>‐positive 970 patients received standard proton pump inhibitor (PPI)‐based triple eradication therapy, and follow‐up <italic>H. pylori</italic> tests were performed with <sup>13</sup>C urea breath test or invasive tests (Giemsa histology, CLO test, and culture) 4 weeks after completion of treatment. A total of 331 patients who were maintained an <italic>H. pylori</italic>‐eradicated state at 1 year after eradication were divided into two groups according to reinfection. For the evaluation of risk factors of reinfection, gender, age, smoking, alcohol, income, education, gastrointestinal symptoms, clinical diagnosis, histologic atrophic gastritis or intestinal metaplasia, and clarithromycin resistance were analyzed.</p> </sec> <sec id="hel12018-sec-0003" sec-type="section"> <title>Results</title> <p>The follow‐up period was 18–95 months (mean: 37.1 months), and <italic>H. pylori</italic> reappeared in 36 of 331 patients (10.9%), resulting in the annual reinfection rate of 3.51% per year. Multivariate analysis showed that male gender (HR 2.28; 95% CI, 1.05–5.00, <italic>p </italic>=<italic> </italic>.037) and low monthly family income (≤5000$ vs >5000$) (HR 3.54; 95% CI, 1.08–11.67, <italic>p </italic>=<italic> </italic>.038) were associated with <italic>H. pylori</italic> reinfection.</p> </sec> <sec id="hel12018-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This long‐term reinfection rate of <italic>H. pylori</italic> stayed rather low (3.51% per year), and male and low income determined the reinfection, factors already known to be important for <italic>H. pylori</italic> infection.</p> </sec> </abstract>