A Quantitative Assessment of the Amount of Prion Diverted to Category 1 Materials and Wastewater During Processing. Issue 7 (24th December 2012)

• Record Type: Journal Article
• Authors: Adkin, Amie; Donaldson, Neil; Kelly, Louise
• Is Part Of: Risk analysis. Volume 33:Issue 7(2013)
• Page Start: 1197
• Page End: 1211
• Publication Date: 2012-12-24
• Subjects: Technology -- Risk assessment -- Periodicals; 658.403
• DOI: 10.1111/j.1539-6924.2012.01922.x
• Languages: English
• ISSNs: 0272-4332

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In this article the development and parameterization of a quantitative assessment is described that estimates the amount of TSE infectivity that is present in a whole animal carcass (bovine spongiform encephalopathy [BSE] for cattle and classical/atypical scrapie for sheep and lambs) and the amounts that subsequently fall to the floor during processing at facilities that handle specified risk material (SRM). BSE in cattle was found to contain the most oral doses, with a mean of 9864 BO ID<sub>50</sub>s (310, 38840) in a whole carcass compared to a mean of 1851 OO ID<sub>50</sub>s (600, 4070) and 614 OO ID<sub>50</sub>s (155, 1509) for a sheep infected with classical and atypical scrapie, respectively. Lambs contained the least infectivity with a mean of 251 OO ID<sub>50</sub>s (83, 548) for classical scrapie and 1 OO ID<sub>50</sub>s (0.2, 2) for atypical scrapie. The highest amounts of infectivity falling to the floor and entering the drains from slaughtering a whole carcass at SRM facilities were found to be from cattle infected with BSE at rendering and large incineration facilities with 7.4 BO ID<sub>50</sub>s (0.1, 29), intermediate plants and small incinerators with a mean of 4.5 BO ID<sub>50</sub>s (0.1, 18), and collection centers, 3.6 BO ID<sub>50</sub>s (0.1, 14). The lowest amounts entering drains are from lambs infected with classical and atypical scrapie at intermediate plants and atypical scrapie at collection centers with a mean of 3 × 10<sup>−7</sup> OO ID<sub>50</sub>s (2 × 10<sup>−8</sup>, 1 × 10<sup>−6</sup>) per carcass. The results of this model provide key inputs for the model in the companion paper published here.</p> </abstract>