Effects of Diagnostic Test Accuracy and Treatment Efficacy on the Occurrence of Suspected Failure of Heartworm Prophylaxis in Dogs. (10th May 2013)

• Record Type: Journal Article
• Authors: Rohrbach, B.W.; Patton, S.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 4(2013:Jul./Aug.)
• Page Start: 791
• Page End: 797
• Publication Date: 2013-05-10
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12092
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12092-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12092-sec-0001" sec-type="section"> <title>Background</title> <p>Food and Drug Administration Center for Veterinary Medicine (FDA/CVM) cited concern regarding failure of heartworm prophylaxis. The positive and negative predictive value of the heartworm antigen test is an estimate of the probability of adult heartworm infection.</p> </sec> <sec id="jvim12092-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>Assess the sensitivity, specificity, and predictive value of heartworm antigen tests. Explore the role of heartworm test accuracy and treatment with immiticide to generate reports of suspected failure of heartworm prophylaxis.</p> </sec> <sec id="jvim12092-sec-0003" sec-type="section"> <title>Methods</title> <p>Literature searches for published information on the accuracy of heartworm antigen tests and efficacy of immiticide for treatment of the adult heartworm.</p> </sec> <sec id="jvim12092-sec-0004" sec-type="section"> <title>Results</title> <p>Weighted averages for heartworm antigen test sensitivity and specificity were 78.2 and 97.3%, respectively. Efficacy of immiticide by 2‐injection or alternate dose protocols were 88.3 and 89.1%, respectively. Depending on prevalence, the positive predictive value of the heartworm antigen test ranged from 15 to 54% and negative predictive value from 99 to 99.9%. For a hospital testing 1, 000 dogs per year, false‐positive test results may vary from 24 to 27 dogs. If these dogs were on heartworm preventive, they may undergo treatment and be classified as prophylaxis failures. Ten percent of dogs who were treated and continued or placed on prophylaxis at the time of treatment may have adult heartworms when tested 1 year later and be presumed to represent failure of prophylaxis.</p> </sec> <sec id="jvim12092-sec-0005" sec-type="section"> <title>Conclusions</title> <p>When interpreting heartworm antigen test results, clinical signs, history, and regional prevalence of heartworm disease should be considered in estimating the predictive value of the test result. Limitations of test and treatment should be discussed with clients as part of the decision‐making process.</p> </sec> </abstract>