Combination therapy with naltrexone and bupropion for obesity reduces total and visceral adiposity. Issue 9 (5th April 2013)

• Record Type: Journal Article
• Authors: Smith, S. R.; Fujioka, K.; Gupta, A. K.; Billes, S. K.; Burns, C.; Kim, D.; Dunayevich, E.; Greenway, F. L.
• Is Part Of: Diabetes, obesity & metabolism. Volume 15:Issue 9(2013:Sep.)
• Page Start: 863
• Page End: 866
• Publication Date: 2013-04-05
• Subjects: Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.12095
• Languages: English
• ISSNs: 1462-8902

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The effects of combination naltrexone/bupropion therapy on body composition and visceral adipose tissue (VAT) mass were examined in a subset (n = 107) of obese subjects from a Phase 2 trial that compared the efficacy and safety of placebo, naltrexone monotherapy, bupropion monotherapy or one of three naltrexone/bupropion dose combinations for 24 weeks. Body composition data were obtained using dual‐energy X‐ray absorptiometry and computed tomography. Eighty subjects completed the substudy. Naltrexone/bupropion resulted in weight loss and a greater reduction in body fat (−14.0 ± 1.3%) than placebo (−4.0 ± 2.0%), naltrexone monotherapy (−3.2 ± 2.5%) and bupropion monotherapy (−4.1 ± 2.9%; all p &lt; 0.01). Reduction in VAT mass was also greater with naltrexone/bupropion (−15.0 ± 1.8%) than placebo (−4.6 ± 2.7%), naltrexone monotherapy (−0.1 ± 3.5%) and bupropion monotherapy (−2.3 ± 4.2%; all p &lt; 0.01). Reductions in body fat and VAT mass with naltrexone/bupropion were proportional with weight loss. Weight loss with naltrexone/bupropion was not associated with a greater relative reduction in lean mass than placebo or the monotherapies.</p> </abstract>