HLA‐DRB, ‐DQA, and DQB alleles and haplotypes in Iranian patients with diabetes mellitus type I. Issue 5 (14th May 2012)

• Record Type: Journal Article
• Authors: Rabbani, Ali; Abbasi, Farzaneh; Taghvaei, Mohammad; Rabbani, Bahareh; Moradi, Batoul; Shakiba, Yadollah; Rezaei, Nima; Amirzargar, Aliakbar
• Is Part Of: Pediatric diabetes. Volume 14:Issue 5(2013)
• Page Start: 366
• Page End: 371
• Publication Date: 2012-05-14
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/j.1399-5448.2012.00869.x
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Specific alleles at the HLA‐DRB1, ‐DQA1, and ‐DQB1 loci seem to be associated with variable risks of developing type 1 diabetes (T1D). This study assessed the distribution of HLA‐DR and ‐DQ alleles among Iranian T1D patients and healthy controls. In this study, HLA‐DRB1, ‐DQA1, and ‐DQB1 alleles were determined in 100 children with T1D and 100 unrelated healthy controls. The following alleles were found to have a strong positive association with T1D: DRB1*0301, DRB1*0401, DRB1*0402, DQA1*0301, DQA1*0501, DQB1*0201, and DQB1*0302. Meanwhile, protective associations were found for DRB1*1001, DRB1*1101, DRB1*15, DRB1*16, DQA1*0102, DQA1*0103, DQB1*0301, DQB1*0501, and DQB1*0602 alleles. The haplotypes found most frequently among patients with T1D were DRB1*0301‐DQA1*0501‐DQB1*0201, DRB1*0401‐DQA1*0301‐ DQB1*0302, and DRB1*0402‐DQA1*0301‐DQB1*0302, whereas DRB1*1101‐DQA1*0501‐DQB1*0301 and DRB1*16‐DQA1*0102‐ DQB1*0501 haplotypes were negatively associated with the disease. These results confirm the previously reported association of specific HLA‐DR and HLA‐DQ alleles and haplotypes with T1D in Iranian population. The notable difference was the identification of DRB1*16‐DQA1*0102‐DQB1*0501 as a protective haplotype and the absence of a negative association of DRB1*1301‐DQA1*0103‐DRB1*0603 with T1D.</p> </abstract>