Prospective multicentre study of the effect of voluntary plasmapheresis on plasma cholesterol levels in donors. Issue 2 (20th March 2013)

• Record Type: Journal Article
• Authors: Rosa‐Bray, M.; Wisdom, C.; Wada, S.; Johnson, B. R.; Grifols‐Roura, V.; Grifols‐Lucas, V.
• Is Part Of: Vox sanguinis. Volume 105:Issue 2(2013)
• Page Start: 108
• Page End: 115
• Publication Date: 2013-03-20
• Subjects: Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/vox.12031
• Languages: English
• ISSNs: 0042-9007

Abstract

<abstract abstract-type="main" id="vox12031-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="vox12031-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>LDL apheresis is used to treat patients with familial hypercholesterolaemia, and low‐volume plasmapheresis for plasma donation may similarly lower cholesterol levels in some donors. This study was designed to assess the effect of plasmapheresis on total, LDL and HDL cholesterol levels in a plasma donor population.</p> </sec> <sec id="vox12031-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>This was a prospective, unblinded longitudinal cohort study in which a blood sample was obtained for analysis before each donation. Data from 663 donors were analysed using a multivariable repeated measures regression model with a general estimating equations approach with changes in cholesterol as the primary outcome measure.</p> </sec> <sec id="vox12031-sec-0003" sec-type="section"> <title>Results</title> <p>The model predicted a significant decrease in total and LDL cholesterol for both genders and all baseline cholesterol levels (<italic>P </italic><<italic> </italic>0·01). The greatest total cholesterol decreases (women, −46·8 mg/dL; men, −32·2 mg/dL) were associated with high baseline levels and 2–4 days between donations. Small but statistically significant increases (<italic>P</italic> ≤ 0·01) in HDL cholesterol were predicted for donors with low baseline levels.</p> </sec> <sec id="vox12031-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These results suggest that, in donors with elevated baseline cholesterol levels, total and LDL cholesterol levels may decrease during routine voluntary plasmapheresis.</p> </sec> </abstract>