Bilateral focal ablation of prostate tissue using low‐energy direct current (LEDC): a preclinical canine study. (23rd July 2013)

• Record Type: Journal Article
• Authors: Tsivian, Matvey; Polascik, Thomas J.
• Is Part Of: BJU international. Volume 112:Number 4(2013:Aug.)
• Page Start: 526
• Page End: 530
• Publication Date: 2013-07-23
• Subjects: Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/bju.12227
• Languages: English
• ISSNs: 1464-4096

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bju12227-sec-0001" sec-type="section"> <title>Objective</title> <p> <list id="bju12227-list-0001" list-type="bullet"> <list-item> <p>To evaluate side‐effects, erectile function and capability to preserve adjacent tissues of bilateral focal prostate ablation using low‐energy direct current (LEDC) in a canine model.</p> </list-item> </list> </p> </sec> <sec id="bju12227-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p> <list id="bju12227-list-0002" list-type="bullet"> <list-item> <p>In all, 12 male Beagle dogs underwent bilateral focal prostate ablation using the NanoKnife™ LEDC system.</p> </list-item> <list-item> <p>Three 19 G monopolar electrodes were transperineally placed on each side of the prostate under transrectal ultrasonographic (TRUS) guidance using a triangular probe array.</p> </list-item> <list-item> <p>Intra‐ and postoperative side‐effects were recorded. Erectile function was evaluated at baseline and 4–5 and 26–27 days after ablation.</p> </list-item> <list-item> <p>The dogs were killed humanely at 7 (six) and 30 days (six) for gross and microscopic evaluation of the prostate and adjacent organs.</p> </list-item> </list> </p> </sec> <sec id="bju12227-sec-0003" sec-type="section"> <title>Results</title> <p> <list id="bju12227-list-0003" list-type="bullet"> <list-item> <p>The median (range) prostate volume on TRUS was 12.1 (8.9–17.2) mL. The electrodes were placed at a median distance of 0.55–0.66 cm from the capsule, urethra and rectum.</p> </list-item> <list-item> <p>All procedures were completed successfully and recovery was uneventful. There were no episodes of urinary retention.</p> </list-item> <list-item> <p>All the dogs were able to achieve erections after ablation.</p> </list-item> <list-item> <p>Pathological analyses revealed inflammatory changes in the ablation zone at 7 days and replacement by fibrosis at 30 days. On microscopic examination no histological injury to the capsule, urethra, rectal wall or nervous structures was identified.</p> </list-item> </list> </p> </sec> <sec id="bju12227-sec-0004" sec-type="section"> <title>Conclusions</title> <p> <list id="bju12227-list-0004" list-type="bullet"> <list-item> <p>In this study, bilateral focal prostate ablation using LEDC was safe and had a favourable side‐effects profile limited to transient minor events.</p> </list-item> <list-item> <p>LEDC ablation effectively spared adjacent structures as well as physiological functions in all the dogs.</p> </list-item> </list> </p> </sec> </abstract>