Prospective longitudinal study of corneal collagen cross‐linking in progressive keratoconus. (14th December 2012)

• Record Type: Journal Article
• Authors: Viswanathan, Deepa; Males, John
• Is Part Of: Clinical & experimental ophthalmology. Volume 41:Number 6(2013)
• Page Start: 531
• Page End: 536
• Publication Date: 2012-12-14
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1111/ceo.12035
• Languages: English
• ISSNs: 1442-6404

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ceo12035-sec-0001" sec-type="section"> <title>Background</title> <p>Collagen cross‐linking has been reported to be effective in treating progressive keratoconus, and this study aims to evaluate the long‐term efficacy of this procedure.</p> </sec> <sec id="ceo12035-sec-0002" sec-type="section"> <title>Design</title> <p>Prospective longitudinal interventional study of patients with progressive keratoconus who underwent cross‐linking in a tertiary referral hospital.</p> </sec> <sec id="ceo12035-sec-0003" sec-type="section"> <title>Participants</title> <p>Thirty‐five patients (51 eyes) who underwent cross‐linking with a mean follow‐up of 14.38 ± 9.36 months (range 6–48) were compared with a control group of 25 fellow eyes that did not undergo the procedure.</p> </sec> <sec id="ceo12035-sec-0004" sec-type="section"> <title>Methods</title> <p>Cross‐linking was performed using 0.1% riboflavin (in 20% dextran T500) and ultraviolet A irradiation (370 nm, 3 mW/cm<sup>2</sup>, 30 min).</p> </sec> <sec id="ceo12035-sec-0005" sec-type="section"> <title>Main Outcome Measures</title> <p>Maximum keratometry in dioptres, logMAR best spectacle‐corrected visual acuity, cylindrical power, manifest refraction spherical equivalent and central corneal thickness.</p> </sec> <sec id="ceo12035-sec-0006" sec-type="section"> <title>Results</title> <p>Analysis of the treated group demonstrated a significant flattening of maximum keratometry by 0.96 ± 2.33 dioptres (<italic>P</italic> = 0.005) and a significant improvement in visual acuity by 0.05 ± 0.13 logMAR (<italic>P</italic> = 0.04). In the control group, maximum keratometry increased significantly by 0.43 ± 0.85 dioptres (<italic>P</italic> = 0.05), and visual acuity decreased by mean 0.05 ± 0.14 (<italic>P</italic> = 0.2). No statistical differences were noted regarding cylindrical power, spherical equivalent or corneal thickness in both groups.</p> </sec> <sec id="ceo12035-sec-0007" sec-type="section"> <title>Conclusions</title> <p>Results indicate that corneal collagen cross‐linking using riboflavin and ultraviolet A is effective as a therapeutic option in cases of progressive keratoconus by reducing the corneal curvature and by improving the visual acuity in these patients.</p> </sec> </abstract>