The effect of coffee consumption on the development of hepatocellular carcinoma in hepatitis B virus endemic area. (8th May 2013)

• Record Type: Journal Article
• Authors: Jang, Eun Sun; Jeong, Sook‐Hyang; Lee, Sang Hyub; Hwang, Sung Ho; Ahn, So Yeon; Lee, Jaebong; Park, Young Soo; Hwang, Jin Hyoek; Kim, Jin‐Wook; Kim, Nayoung; Lee, Dong Ho; Kim, Hyun Young
• Is Part Of: Liver international. Volume 33:Number 7(2013:Aug.)
• Page Start: 1092
• Page End: 1099
• Publication Date: 2013-05-08
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.12186
• Languages: English
• ISSNs: 1478-3223

Abstract

<abstract abstract-type="main" id="liv12186-abs-0001"> <title>Abstract</title> <sec id="liv12186-sec-0001" sec-type="section"> <title>Background & Aims</title> <p>Coffee consumption is inversely related to the risk of cirrhosis or hepatocellular carcinoma (HCC). However, the protective effect of coffee drinking against the risk of HCC was not established in HBV‐prevalent region. To elucidate the relationship between lifetime coffee consumption and the risk of HCC development under the consideration of replication status of HBV.</p> </sec> <sec id="liv12186-sec-0002" sec-type="section"> <title>Methods</title> <p>A hospital‐based case–control study was performed in 1364 subjects. A total of 258 HCC patients, 480 health‐check examinees (control 1, HCE) and 626 patients with chronic liver disease other than HCC (control 2, CLD) were interviewed on smoking, alcohol and coffee drinking using a standardized questionnaire. HBV e‐antigen (HBeAg) status and serum HBV DNA levels were measured in patients infected with HBV.</p> </sec> <sec id="liv12186-sec-0003" sec-type="section"> <title>Results</title> <p>After adjustment for age, gender, obesity, DM, presence of hepatitis virus (except for HCE) and lifetime alcohol drinking/smoking, a high lifetime coffee consumption (≥20 000 cups) was an independent protective factor against HCC, in each analyses using healthy and risky control groups respectively (HCE group, OR 0.56, 95% CI 0.33–0.95; CLD group, OR 0.55, 95% CI 0.36–0.85). However, the high coffee consumption did not affect the HCC risk in patients with HBV (OR 0.64, 95% CI 0.36–1.14) after adjustment for HBeAg status, serum HBV DNA level and antiviral therapy.</p> </sec> <sec id="liv12186-sec-0004" sec-type="section"> <title>Conclusions</title> <p>A high lifetime coffee consumption was negatively associated with a HCC development. However, this difference of coffee exposure with the HCC group was reduced in chronic hepatitis B patients by the dominant role of viral replication.</p> </sec> </abstract>