Recurrence of preterm birth and perinatal mortality in northern Tanzania: registry‐based cohort study. Issue 8 (13th April 2013)

• Record Type: Journal Article
• Authors: Mahande, Michael J.; Daltveit, Anne K.; Obure, Joseph; Mmbaga, Blandina T.; Masenga, Gileard; Manongi, Rachel; Lie, Rolv T.
• Is Part Of: Tropical medicine & international health. Volume 18:Issue 8(2013:Aug.)
• Page Start: 962
• Page End: 967
• Publication Date: 2013-04-13
• Subjects: Tropical medicine -- Periodicals; Public health -- Periodicals; 616.988
• DOI: 10.1111/tmi.12111
• Languages: English
• ISSNs: 1360-2276

Abstract

<abstract abstract-type="main" id="tmi12111-abs-0001"> <title>Abstract</title> <sec id="tmi12111-sec-0001" sec-type="section"> <title>Objectives</title> <p>To estimate the recurrence risk of preterm delivery and estimate the perinatal mortality in repeated preterm deliveries.</p> </sec> <sec id="tmi12111-sec-0002" sec-type="section"> <title>Methods</title> <p>Prospective study in Tanzania of 18 176 women who delivered a singleton between 2000 and 2008 at KCMC hospital. The women were followed up to 2010 for consecutive births. A total of 3359 women were identified with a total of 3867 subsequent deliveries in the follow‐up period. Recurrence risk of preterm birth and perinatal mortality was estimated using log‐binomial regression and adjusted for potential confounders.</p> </sec> <sec id="tmi12111-sec-0003" sec-type="section"> <title>Results</title> <p>For women with a previous preterm birth, the risk of preterm birth in a subsequent pregnancy was 17%. This recurrence risk was estimated to be 2.7‐fold (95% CI: 2.1–3.4) of the risk of women with a previous term birth. The perinatal mortality of babies in a second preterm birth of the same woman was 15%. Babies born at term who had an older sibling that was born preterm had a perinatal mortality of 10%. Babies born at term who had an older sibling who was also born at term had a perinatal mortality of 1.7%.</p> </sec> <sec id="tmi12111-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Previous delivery of a preterm infant is a strong predictor of future preterm births in Tanzania. Previous or repeated preterm births increase the risk of perinatal death substantially in the subsequent pregnancy.</p> </sec> </abstract>