Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheumatoid arthritis in Zahedan, Southeast Iran. (27th January 2013)

• Record Type: Journal Article
• Authors: Hashemi, M.; Atabaki, M.; Daneshvar, H.; Zakeri, Z.; Eskandari‐Nasab, E.
• Is Part Of: International journal of immunogenetics. Volume 40:Number 4(2013:Aug.)
• Page Start: 299
• Page End: 305
• Publication Date: 2013-01-27
• Subjects: Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12038
• Languages: English
• ISSNs: 1744-3121

Abstract

<abstract abstract-type="main" xml:lang="en" id="iji12038-abs-0001"> <title>Summary</title> <p>In this study we aimed to evaluate the possible association of <italic>PTPN22</italic> rs2476601 as well as epidermal growth factor receptor (EGFR) rs17337023 gene polymorphism and rheumatoid arthritis (RA) in a sample of Iranian population. This case‐control study was performed on 120 patients with RA and 120 healthy subjects. Genomic DNA was extracted from whole blood and <italic>PTPN22</italic> rs2476601 and EGFR rs17337023 polymorphisms were determined using tetra amplification refractory mutation system–polymerase chain reaction (T‐ARMS‐PCR). The results showed that <italic>PTPN22</italic> rs2476601 CT genotype as well as rs2476601 T allele was a risk factor for susceptibility to RA (OR=5.89 95%CI = 1.78–19.48, <italic>P</italic> = 0.004 and OR = 4.78, 95%CI = 1.59–14.35, <italic>P</italic> = 0.003, respectively). We also found that EGFR rs17337023 AT and rs17337023 TT genotypes were risk factor for susceptibility to RA (OR = 9.94 95%CI = 3.65–26.73, <italic>P</italic> &lt; 0.001 and OR = 3.66, 95%CI = 1.46–9.15, <italic>P</italic> = 0.005, respectively). In addition the EGFR rs17337023 T allele was a risk for predisposition to RA (OR = 1.56, 95%CI=1.06‐2.30, P = 0.030). In conclusion, we found an association between <italic>PTPN22</italic> rs2476601 and EGFR rs17337023 polymorphisms and the risk of RA in a sample of Iranian population.</p> </abstract>