Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats. (July 2013)

• Record Type: Journal Article
• Authors: Afzal, Muhammad; Kazmi, Imran; Kaur, Rupinder; Ahmad, Aftab; Pravez, Mohammad; Anwar, Firoz
• Is Part Of: Pharmaceutical biology. Volume 51:Number 7(2013:Jul.)
• Page Start: 856
• Page End: 862
• Publication Date: 2013-07
• Subjects: Pharmacognosy -- Periodicals; Materia medica, Vegetable -- Periodicals; 615.321
• DOI: 10.3109/13880209.2013.767840
• Languages: English
• ISSNs: 1388-0209

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: <italic>Daucus carota</italic> Linn (Apiaceae), a useful vegetable, is traditionally used in treating kidney and hepatic dysfunctions.</p> <p> <italic>Objective:</italic> To evaluate the protective and curative potential of <italic>D. carota</italic> root extract on renal ischemia reperfusion injury in rats.</p> <p> <italic>Materials and methods</italic>: Wistar rats were selected with 8 + 8 groups (<italic>n</italic> = 6). Renal pedicles of rats were occluded for 45 min and allowed for reperfusion period. In protective and curative studies, 14 days prior and 14 days after the induction of ischemia/reperfusion (I/R), rats received petroleum ether extract (PEE 250 and 500 mg/kg), fractional methanol extract (FME 250 and 500 mg/kg) and direct methanol extract (DME 250 and 500 mg/kg) of <italic>Daucus carota</italic> root, orally, once daily.</p> <p> <italic>Results</italic>: PEE at a dose of 500 mg/kg significantly (<italic>p</italic> < 0.001) reduced the levels of serum creatinine (0.853–3.090 mg/dl), uric acid (1.300–3.500 mg/dl) and urea (58.26–132.00 mg/dl) compared to disease control. FME at a dose of 500 mg/kg body weight significantly (<italic>p</italic> < 0.001) reduced the levels of serum creatinine (0.960–3.090 mg/dl), uric acid (1.700–3.500 mg/dl) and urea (77.17–132.00 mg/dl) compared to disease control. DME at a dose of 500 mg/kg body weight significantly (<italic>p</italic> < 0.001) reduced the levels of serum creatinine (1.173–3.090 mg/dl), uric acid (2.267–3.500 mg/dl) and urea (84.75–132.00 mg/dl) compared to disease control.</p> <p> <italic>Discussion and conclusion</italic>: Findings demonstrate that postconditioning with the <italic>D. carota</italic> root extract significantly improves kidney function in I/R rats.</p> </abstract>