Self-assembled carbohydrate hydrogels for prolonged pain management. (October 2013)

• Record Type: Journal Article
• Authors: Kamel, R.; Abbas, H. A.
• Is Part Of: Pharmaceutical development and technology. Volume 18:Number 5(2013)
• Page Start: 990
• Page End: 1004
• Publication Date: 2013-10
• Subjects: Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2011.609992
• Languages: English
• ISSNs: 1083-7450

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Context</italic>: Nanoparticulate systems are new tools that promise a revolution in the field of drug delivery. Among their numerous benefits, polyelectrolyte complexes (PECs) have shown to provide a barrier to drug release.</p> <p> <italic>Objective</italic>: In this study, PECs, in the form of self-assembled polymeric nanogels, have been studied as potential drug carriers of the freely soluble drug tramadol HCL trying to achieve a prolonged percutaneous permeation.</p> <p> <italic>Methodology</italic>: The hydrogels were subjected to swelling, rheology, release and permeation studies and were characterized by FTIR spectroscopy and scanning electron microscopy.</p> <p> <italic>Results</italic>: P2 hydrogel composed of chitosan-carrageenan (1-1) PEC attained the most compromised rheological shear-thinning thixotropic behavior, good bioadhesive properties, the most retarded release and permeation with an <italic>f2</italic> value &lt;50 compared to chitosan hydrogel, altogether with non-irritancy to the skin. SEM photographs showed that P2 has spherical nanosized particles structure.</p> <p> <italic>Conclusion</italic>: This approach can provide us promising results for an around-the-clock analgesia with better safety and tolerability profile.</p> </abstract>