Prenatal dolichocephaly: Sign of trouble? –A variant of Miller–Dieker syndrome. (10th July 2013)

• Record Type: Journal Article
• Authors: Kochuvareed Mampilly, Tomy; Tomy Mampilly, George; Chandramohan, Neeradha; Velayutham, Murugan; Sheth, Jayesh; Sheth, Frenny; Janaki, Vijayalakshmy
• Is Part Of: Fetal and pediatric pathology. Volume 32:Number 4(2013)
• Page Start: 308
• Page End: 311
• Publication Date: 2013-07-10
• Subjects: Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2012.754529
• Languages: English
• ISSNs: 1551-3815

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Neuroimaging and molecular cytogenetics were used to ascertain the cause of disability in a case. The case was diagnosed to be a variant of Miller–Dieker syndrome (MDS). Retrospective analysis showed a prenatal scan reporting dolichocephaly. We evaluated dolichocephaly, the name associated with a nonsynostotic cause to be a physiological variant having no prognostic value, to that of a similar synostotic or secondary to a neurological disorder cause, with prognostic significance. The report confirmed early craniosynostosis in cases suspected with a neurological disorder and also on an important criterion in molecular testing strategy in cases suspected with MDS.</p> </abstract>