Preparation and characterization of mosapride citrate inclusion complexes with natural and synthetic cyclodextrins. (October 2013)

• Record Type: Journal Article
• Authors: Ali, Adel A.; Sayed, Ossama M.
• Is Part Of: Pharmaceutical development and technology. Volume 18:Number 5(2013)
• Page Start: 1042
• Page End: 1050
• Publication Date: 2013-10
• Subjects: Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2011.646425
• Languages: English
• ISSNs: 1083-7450

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>The aim of this work was to investigate the inclusion complexes between mosapride citrate and SBE₇<italic>β</italic>-CD in comparison with the natural <italic>β</italic>-CD to enhance its bioavailability by improving the solubility and dissolution rate. The complexation efficiency value of SBE₇<italic>β-</italic>CD was higher than that for <italic>β</italic>-CD. Solid binary systems of mosapride citrate with CDs were prepared by physical mixing, kneading and freeze-drying techniques at molar ratio of 1:1(drug:CD). Physicochemical characterization of the prepared systems was studied using X-ray diffractometry, differential scanning calorimetry, Fourier-transform infrared spectroscopy and scanning electron microscopy (SEM). Amorphous drug was detectable to large extent in inclusion complexes prepared using the freeze-drying technique. From the dissolution study of different inclusion complexes in simulated saliva solution (pH 6.8), we could concluded that irrespective of the preparation technique, the systems prepared using SBE₇<italic>β</italic>-CD showed better performance than the corresponding ones prepared using <italic>β</italic>-CD. In addition, the freeze-drying technique showed superior dissolution enhancement than other methods especially when combined with the SBE₇<italic>β</italic>-CD</p> </abstract>