Swine liver methylomes of Berkshire, Duroc and Landrace breeds by MeDIPS. (27th February 2013)

• Record Type: Journal Article
• Authors: Bang, Woo Young; Kim, Sam Woong; Kwon, Seul Gi; Hwang, Jung Hye; Kim, Tae Wan; Ko, Moon‐Suck; Cho, In‐Cheol; Joo, Young Kuk; Cho, Kwang Keun; Jeong, Jin Young; Kim, Chul Wook
• Is Part Of: Animal genetics. Volume 44:Number 4(2013:Aug.)
• Page Start: 463
• Page End: 466
• Publication Date: 2013-02-27
• Subjects: Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12030
• Languages: English
• ISSNs: 0268-9146

Abstract

<abstract abstract-type="main" id="age12030-abs-0001"> <title>Summary</title> <p>Using a methyl‐DNA immunoprecipitation technique in combination with next‐generation deep sequencing, we conducted comprehensive DNA methylation profiling of liver genomes from three pig breeds: Berkshire, Duroc and Landrace. The profiles revealed that the distribution patterns of methylation signals along the genome are conserved among the three pig breeds. Specifically, many signals in coding genes were found in introns, and most signals in the repetitive elements were identified in non‐long terminal repeat (LTR) retrotransposons such as long and short interspersed repetitive elements, implying a significant association with alternative splicing and expression of retrotransposable elements respectively. Differentially methylated regions among the three pig breeds were identified in the non‐LTR retrotransposons, suggesting that they may lead to differential retrotransposable element activity. Altogether, this study provides advanced swine methylome data and valuable resources for understanding the function of DNA methylation in the evolutionary divergence of different pig breeds.</p> </abstract>