Performance of screening algorithms in systemic sclerosis‐related pulmonary arterial hypertension: a systematic review. Issue 7 (11th July 2013)

• Record Type: Journal Article
• Authors: Thakkar, V.; Stevens, W. M.; Moore, O. A.; Nikpour, M.
• Is Part Of: Internal medicine journal. Volume 43:Issue 7(2013)
• Page Start: 751
• Page End: 760
• Publication Date: 2013-07-11
• Subjects: Medicine -- Periodicals; 616
• DOI: 10.1111/imj.12167
• Languages: English
• ISSNs: 1444-0903

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="imj12167-sec-0001" sec-type="section"> <title>Background</title> <p>Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc). There is emerging evidence that screening may enable the earlier detection and treatment of SSc‐PAH, and thereby improve survival.</p> </sec> <sec id="imj12167-sec-0002" sec-type="section"> <title>Aims</title> <p>We undertook a systematic review to evaluate the performance of current screening algorithms in SSc‐PAH.</p> </sec> <sec id="imj12167-sec-0003" sec-type="section"> <title>Methods</title> <p>We searched the Medline and EMBASE databases to 31 March 2012. We selected studies if they applied a screening algorithm to consecutively enrolled SSc patients not known to have PAH; SSc‐PAH had to be confirmed on right heart catheterisation (RHC). The performance of each screening algorithm and the methodological quality of each study was evaluated.</p> </sec> <sec id="imj12167-sec-0004" sec-type="section"> <title>Results</title> <p>Nine studies met the inclusion criteria with a total intent‐to‐screen population of 3504 participants. In studies of patients with prevalent disease, the positive predictive value (PPV) of screening for PAH was 20.4–87.0%. In studies of patients with incident disease, the PPV of screening for PAH was 20.0–30.7%. The PPV of algorithms using echocardiography alone, or in combination with other tests, was comparable. No study enabled an accurate determination of negative predictive value, sensitivity or specificity of the screening algorithm as only patients who screened positive underwent confirmatory testing with RHC. The optimal timing and frequency of repeat screening is unknown.</p> </sec> <sec id="imj12167-sec-0005" sec-type="section"> <title>Conclusion</title> <p>The low to moderate PPV of current screening algorithms, coupled with the inability to determine accurately the negative predictive value, sensitivity and specificity, suggests that there is a need to validate further these algorithms before making recommendations regarding screening for SSc‐PAH.</p> </sec> </abstract>